Medical Oncology

Adrenocortical Carcinoma

Questions discussed in this category

For a completely resected high risk adrenal cortical carcinoma with a high mitotic rate, what is your approach to adjuvant therapy?

When do you use mitotane?

1 Answer available

Would you offer immunotherapy first line for patients with adrenocortical carcinoma outside of a clinical trial?

The phase 2 trial of pembrolizumab in JCO 2019 showed efficacy, and I have patients preferring to avoid chemotherapy.

1 Answer available

Papers discussed in this category

J Endocr Soc, 2019 Oct 11

Response to Immunotherapy in Combination With Mitotane in Patients With Metastatic Adrenocortical Cancer.

J Clin Oncol, 2020 Jan 1

PD-1 Blockade in Advanced Adrenocortical Carcinoma.

Journal of the American College of Surgeons, 2016-04

Outcomes of Adjuvant Mitotane after Resection of Adrenocortical Carcinoma: A 13-Institution Study by the US Adrenocortical Carcinoma Group.

Urol Oncol, 2021 Jul 20

Identification of oncological characteristics associated with improved overall survival in patients with adrenocortical carcinoma treated with adjuvant radiation therapy: Insights from the National Cancer Database.

N Engl J Med,

Adjuvant mitotane treatment for adrenocortical carcinoma.

Cancers (Basel), 2020 Sep 14

Unwanted Hormonal and Metabolic Effects of Postoperative Adjuvant Mitotane Treatment for Adrenocortical Cancer.

Am J Surg, 2020 Nov 04

Analysis of adjuvant chemotherapy in patients undergoing curative-intent resection of localized adrenocortical carcinoma.

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