Medical Oncology

Discordant HER2

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What adjuvant systemic therapy would you recommend for a premenopausal woman with a germline BRCA mutation who initially presented with locally advanced, HR+, HER2 neg(FISH) IDC, but was later found on surgical pathology to have HR+, HER2+ disease (IHC 3+) after neoadjuvant chemotherapy?

Initially, presented with cT2N3M0 IDC, ER/PR+, HER2 negative (FISH) on pre-operative biopsies (breast and axilla)-->Got neoadjuvant AC-T-->Later...

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