Neurosurgery

Lung Cancer

Questions discussed in this category

Is it acceptable to treat newly diagnosed small cell lung cancer with limited brain metastasis with upfront SRS?

This has become standard practice at our institution for patients with a good performance status, with whole brain radiotherapy given after the comple...

12 Answers available

Would you offer post-operative SRS/SBRT in the case of a resected brain metastasis from metastatic NSCLC with an EGFR mutation?

With targeted therapies available, is there a utility for post-op SRS to the resection cavity?

2 Answers available

How would you manage a patient with surgically resected T3N1 NSCLC who is found to have one small brain metastasis on staging MRI?

In addition to addresing the brain met (surgery vs. SBRT), would you proceed with systemic "adjuvant" chemotherapy, or would you treat the patient as ...

3 Answers available

Papers discussed in this category

N Engl J Med, 2007 Aug 16

Prophylactic cranial irradiation in extensive small-cell lung cancer.

J Clin Oncol, 1999 Jul

Role of radiation therapy in the combined-modality treatment of patients with extensive disease small-cell lung cancer: A randomized study.

Lancet, 2015 Jan 3

Use of thoracic radiotherapy for extensive stage small-cell lung cancer: a phase 3 randomised controlled trial.

International journal of radiation oncology, biology, physics, 2011-11-01

Stereotactic radiosurgery for patients with brain metastases from small cell lung cancer.

Int. J. Radiat. Oncol. Biol. Phys., 2006-09-01

A pathology-based substrate for target definition in radiosurgery of brain metastases.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2017-12

Prophylactic Cranial Irradiation (PCI) versus Active MRI Surveillance for Small Cell Lung Cancer: The Case for Equipoise.

Lancet Oncol., 2017-05-01

Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial.

The New England journal of medicine, 1999-08-12

Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group.

BMC Cancer, 2015-08-15

Management of brain metastasis with magnetic resonance imaging and stereotactic irradiation attenuated benefits of prophylactic cranial irradiation in patients with limited-stage small cell lung cancer.

Journal of cancer research and therapeutics, 2012

Clinical outcomes of reirradiation of brain metastases from small cell lung cancer with Cyberknife stereotactic radiosurgery.

International journal of radiation oncology, biology, physics, 2012-05-01

Gamma knife stereotactic radiosurgery as salvage therapy after failure of whole-brain radiotherapy in patients with small-cell lung cancer.

Neurosurgery, 2013-10

Tumor histology predicts patterns of failure and survival in patients with brain metastases from lung cancer treated with gamma knife radiosurgery.

Practical radiation oncology, 2015

Local recurrence and survival following stereotactic radiosurgery for brain metastases from small cell lung cancer.

J. Neurosurg., 2005-01-01

Radiosurgery for patients with recurrent small cell lung carcinoma metastatic to the brain: outcomes and prognostic factors.

J Korean Neurosurg Soc, 2011-08-01

The role of radiosurgery in patients with brain metastasis from small cell lung carcinoma.

Radiat Oncol, 2014-07-08

Upfront stereotactic radiosurgery in patients with brain metastases from small cell lung cancer: retrospective analysis of 41 patients.

BMC Cancer, 2015-03-04

Is stereotactic radiosurgery a rational treatment option for brain metastases from small cell lung cancer? A retrospective analysis of 70 consecutive patients.

Acta Neurochir (Wien), 2013-01-01

Efficacy and limitations of salvage gamma knife radiosurgery for brain metastases of small-cell lung cancer after whole-brain radiotherapy.

The Lancet. Oncology, 2009-11

Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007-04-01

Regression after whole-brain radiation therapy for brain metastases correlates with survival and improved neurocognitive function.

J Clin Oncol, 2011 Jan 10

Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study.

JAMA, 2016-07-26

Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases: A Randomized Clinical Trial.

Radiation oncology (London, England), 2014-09-30

Stereotactic radiosurgery alone for small cell lung cancer: a neurocognitive benefit?

Cancer, 2016-06-15

Risk of brain metastases in patients with nonmetastatic lung cancer: Analysis of the Metropolitan Detroit Surveillance, Epidemiology, and End Results (SEER) data.

J. Clin. Oncol., 2018 May 22

Prophylactic Cranial Irradiation Versus Observation in Radically Treated Stage III Non-Small-Cell Lung Cancer: A Randomized Phase III NVALT-11/DLCRG-02 Study.

Lung cancer (Amsterdam, Netherlands), 2018-06

Radiosurgery alone is associated with favorable outcomes for brain metastases from small-cell lung cancer.

The New England journal of medicine, 2018-08-23

Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain.

The New England journal of medicine, 2018-12-06

First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer.

International journal of radiation oncology, biology, physics, 2019-04-01

Observe the Brain and Preserve the Mind.

Lancet, 2019 Oct 04

Durvalumab plus platinum-etoposide versus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial.

JAMA oncology, 2019-06-01

Prophylactic Cranial Irradiation vs Observation in Patients With Locally Advanced Non-Small Cell Lung Cancer: A Long-term Update of the NRG Oncology/RTOG 0214 Phase 3 Randomized Clinical Trial.

International journal of radiation oncology, biology, physics, 2019-04-01

A Gray Zone Regarding Gray Matter.

International journal of radiation oncology, biology, physics, 2019-04-01

Small Cell Lung Cancer: PCI Uncertainty and Emerging Radiosurgery Interest.

Neurosurgery, 2019 Oct 10

Role of Gamma Knife Radiosurgery in Small Cell Lung Cancer: A Multi-Institutional Retrospective Study of the International Radiosurgery Research Foundation (IRRF).

JAMA Oncol, 2020 Jun 4

Evaluation of First-line Radiosurgery vs Whole-Brain Radiotherapy for Small Cell Lung Cancer Brain Metastases: The FIRE-SCLC Cohort Study.

J Clin Oncol, 2020 Aug 10

Radiosurgery for Small-Cell Brain Metastases: Challenging the Last Bastion of Preferential Whole-Brain Radiotherapy Delivery.

Lung Cancer, 2014 Aug 02

Metastatic sites and survival in lung cancer.

N Engl J Med,

The Effect of Advances in Lung-Cancer Treatment on Population Mortality.

Lancet Oncol, 2020 Apr 03

Pembrolizumab for management of patients with NSCLC and brain metastases: long-term results and biomarker analysis from a non-randomised, open-label, phase 2 trial.

Int J Radiat Oncol Biol Phys,

Neurocognitive outcome in brain metastases patients treated with accelerated-fractionation vs. accelerated-hyperfractionated radiotherapy: an analysis from Radiation Therapy Oncology Group Study 91-04.

JAMA,

Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial.

J Neurosurg,

Gamma knife radiosurgery for metastatic brain tumors from lung cancer: a comparison between small cell and non-small cell carcinoma.

Cancer,

Leptomeningeal metastases from small cell lung carcinoma.

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