Radiation Oncology

Cholangiocarcinoma

Questions discussed in this category

How do you sequence hypofractionated radiation and systemic therapy for patients with unresectable cholangiocarcinoma?

When using hypofractionated RT (i.e., 67.5 Gy in 15 fractions), can chemotherapy be delivered concurrently? Options for systemic therapy in NCC...

2 Answers available

For inoperable cholangiocarcinoma, do you recommend up-front chemotherapy prior to offering SBRT or combination chemoradiation?

1 Answer available

In the Nebraska/Mayo transplant protocol for perihilar cholangiocarcinoma, do you ever offer prophylactic biliary drainage/stenting to prevent obstruction post-chemoradiation?

If the patient had PSC and baseline atrophy preventing brachytherapy boost (received SBRT boost instead), would this change your threshold for stentin...

1 Answer available

In stage 4 hilar cholangiocarcinoma, after stenting the biliary tree is there value in radiating the hilar area in addition to systemic therapy so as to maintain patency of the biliary system for a longer period of time or do you depend on the systemic therapy and the stenting alone?

1 Answer available

Is there a role for pre-operative RT (+/-chemo) for a borderline resectable Klatskin tumor as an attempt to try to get them to surgery?

1 Answer available

Papers discussed in this category

Advances in radiation oncology, 2016

Stereotactic body radiotherapy (SBRT) for locally advanced extrahepatic and intrahepatic cholangiocarcinoma.

Gastroenterology, 2012-07

Efficacy of neoadjuvant chemoradiation, followed by liver transplantation, for perihilar cholangiocarcinoma at 12 US centers.

Brachytherapy, 2018

Technique for the administration of high-dose-rate brachytherapy to the bile duct using a nasobiliary catheter.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-01-20

Ablative Radiotherapy Doses Lead to a Substantial Prolongation of Survival in Patients With Inoperable Intrahepatic Cholangiocarcinoma: A Retrospective Dose Response Analysis.

N. Engl. J. Med.,

Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer.

Pract Radiat Oncol, 2021 Oct 21

External Beam Radiation Therapy for Primary Liver Cancers: An ASTRO Clinical Practice Guideline.

Lancet (London, England), 2023 Apr 16

Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial.

NEJM evidence, 2022 Jun 01

Durvalumab plus Gemcitabine and Cisplatin in Advanced Biliary Tract Cancer.

Radiation Oncology

Cholangiocarcinoma

Questions discussed in this category

Papers discussed in this category

Related Topics in Radiation Oncology