Radiation Oncology

What high risk pathology factors would you consider in making your decision one way or another?Would it matter if this patient was elderly vs young? W...

2 Answers available

What dose constraints, if any, do you use for the thyroid gland when treating with regional nodal irradiation for breast cancer?

1 Answer available

What clinicopathologic features do you consider when deciding whether or not to use a PMRT scar boost?

2 Answers available

What treatment planning challenges do you consider when treating a woman with synchronous bilateral breast cancers?

For example, what is the minimal acceptable distance between the medial tangents?

1 Answer available

Does the presence of an ATM mutation impact your fractionation regimen for a woman with breast cancer?

2 Answers available

Would you consider an axillary dissection in a young patient with high grade breast cancer and one sentinel LN with isolated tumor cells?

2 Answers available

If treating a patient with prior breast augmentation with whole breast radiation, would you alter your field setup?

For standard tangential radiation would you pull the field edge forward to avoid radiation dose to the entire implant?

3 Answers available

Do you consider regional nodal irradiation for women with ER+ breast cancer with a single micrometastasis after lumpectomy and sentinel lymph node sampling?

Would T stage, Oncotype or any other factor affect your decision?

1 Answer available

Following mastectomy with a SNB and single positive axillary lymph node, would you refer a patient back for an axillary dissection if she has borderline indications for PMRT?

For example, for T2N1a ER+ disease? Or would you offer PMRT and axillary nodal irradiation (as a replacement for ALND)?

1 Answer available

How are you using DCISionRT (PreludeDx) in the management of DCIS?

What advantages/disadvantages are there over OncotypeDx DCIS assay or traditional clinical pathologic factors? What other concerns do you have?

3 Answers available

How do you approach the discussion of omission vs. adjuvant radiation in patients with low to intermediate grade DCIS?

2 Answers available

Do you consider SABR for oligometastatic disease in patients with TP53 germline mutation?

In a patient with their second cancer, with oligometastatic disease, do the risks of RT related second malignancies outweigh the benefits?

1 Answer available

How do you decide between high tangents or regional nodal radiation in patients with small, ER+ breast cancers who have a single positive sentinel node?

2 Answers available

How would your recommendations for post-mastectomy radiation change for a patient with scleroderma?

1 Answer available

Do you offer concomitant chemotherapy and radiation to patients with locally advanced ulcerated breast masses that have good performance status and are potentially curable?

1 Answer available

How, if at all, do you use biozorb to help guide your external beam partial breast irradiation volumes?

1 Answer available

For APBI, do you prefer a brachytherapy or external beam technique?

What specific technique (i.e. interstitial vs intracavitary, 3DCRT vs IMRT) do you prefer? What do you consider to be the pros and cons with each appr...

1 Answer available

How do you deliver whole breast radiation to a woman with pectus excavatum?

What techniques are most effective to minimize contralateral breast, heart, and lung dose? Do you recommend conventional fractionation?

3 Answers available

Would you recommend adjuvant radiation to the chest wall and/or regional lymphatics after a resected chest wall recurrence?

Assume no nodal involvement.

2 Answers available

In the case of a high upper outer quadrant early stage breast cancer without adverse histological factors, would you omit boosting the breast lumpectomy cavity if the treatment area would involve a significant portion of axilla due to risk of lymphedema?

Assume the patient had axillary lymph node dissection and taxane chemotherapy. How would you counsel the patient about risk of lymphedema?

2 Answers available

Would you recommend nodal irradiation in a patient with breast cancer with a single positive sentinel node and a low Oncotype who does not receive chemotherapy?

2 Answers available

When do you recommend prone breast radiation?

Are there any quantitative measures that you use to help select patients such as breast size or heart dose? Or do you use a case-by-case qualita...

2 Answers available

Should special precautions be taken when treating oligometastatic disease in the sacrum or pelvis with SBRT in a patient with a long life expectancy?

For example in a patient with a good performance status and a biologically favorable cancer (ER+ breast cancer, EGFR+ NSCLC, or prostate cancer), are ...

1 Answer available

Would you recommend reirradiation in a patient who has extensive subcutaneous chest wall nodules and axillary recurrence after previous PMRT?

1 Answer available

How would you treat a patient who has a large DCIS status post mastectomy and implant with extensive positive margins?

Does the permanent implant change your dose?

1 Answer available

When do you consider using protons for breast cancer?

1 Answer available

What is the threshold for negative surgical margins in multifocal microinvasive carcinoma of the breast?

Do you follow invasive or DCIS guidelines? Would you consider re-excision in a patient with multifocal microinvasive carcinoma of the breast arising i...

2 Answers available

How would you approach an elderly patient with early stage breast cancer with micropapillary histology?

Would you recommend observation? Whole breast irradiation? APBI?

1 Answer available

What is your preferred approach to PMRT with inflammatory breast cancer with adverse risk features?

What is your preferred approach to PMRT with inflammatory breast cancer with adverse risk features (i.e. age <45, close/positive margins or poor re...

2 Answers available

How do you approach positioning and irradiation of breast cancer in accessory breast tissue in the axilla? If the accessory breast tissue extends into the arm, how would you position/immobilize the arm?

What if this lesion was at the top of the hair bearing skin of the axilla?

1 Answer available

Do you use the NM lymphoscintigram during sentinel node identification to decide whether to treat the internal mammary nodes?

1 Answer available

Would you recommend covering the dissected axilla in your radiation field in patients with cN2/N3 disease who had complete response to neoadjuvant chemo and an ALND?

What if ALND reveals no residual disease?

2 Answers available

Would you recommend hypofractionated PMRT with a positive deep margin?

How would you dose?

1 Answer available

Do you offer APBI to patients with PALB2 mutation who is a suitable candidate?

1 Answer available

What dosimetric concerns do you have regarding PMRT in patients with magnetic valve tissue expanders?

These devices give off a significant amount of artifact on CT and some devices say they are a relative contraindication with adjuvant RT.

1 Answer available

How do you image when using DIBH with breast treatment?

Do you use portal or orthogonal imaging or both?

3 Answers available

How do you treat encapsulated papillary carcinoma of the breast after lumpectomy with negative margins?

Do you recommend observation, APBI, whole breast or whole breast with low axilla treatment?

1 Answer available

For patients undergoing breast conservation therapy, how do you ensure dose to the skin during treatment planning?

What is an adequate dose to the skin?

1 Answer available

Do you recommend additional nodal boost in patients with suspicious internal mammary nodes that respond completely after neoadjuvant chemotherapy?

This boost would be in addition to the standard regional nodal irradiation delivered post-op.

1 Answer available

Do you prescribe silvadene cream for patients with a sulfa allergy?

2 Answers available

Do you ever use VMAT for breast cancer?

If so, what clinical indications? Are there any advantages of VMAT? Thoughts on concerns regarding lung and heart dose constraints?

2 Answers available

Would you offer nodal RT for pT2N0 triple negative breast cancer s/p BCS?

Or would you offer high tangents with hypofractionation?

3 Answers available

How soon after completing radiation should anti-estrogen medication start?

Some oncologists wait 1 day, 1 week or 1 month? Is there a preferred waiting period?

5 Answers available

Would you recommend PMRT in a patient with a microinvasive component but a large DCIS component who had a mastectomy with negative margins?

What size of DCIS would make you concerned? Would you estimate the risk of recurrence with and without radiation?

1 Answer available

Would you consider treating the regional nodes in addition to the breast in a patient with skin involvement (pT4b) after a lumpectomy with negative margins/nodes who refuses chemotherapy?

Would a limited axillary dissection influence your decision? Any other risk factors that would sway your decision?

2 Answers available

Do you routinely treat the anterior oblique breast suprclav field with 6MV photons or do you use a higher dose, such as 10+ MV?

What's the minimum isodose coverage line you accept for coverage of higher level axillary lymph nodes?

1 Answer available

Do you request lumpectomy cavity markers to be placed at time of surgery to guide planning?

Do you find such markers such as biozorb to be more helpful than delineating the seroma and/or clips on CT? When is this useful? During ...

3 Answers available

Would you consider PMRT in a patient with N0(i+) luminal A disease?

Does the T stage influence your decision (for example, T1mic)? Would multiple positive nodes showing isolated tumor cells sway your decision?

1 Answer available

When would you recommend delaying PMRT until after breast reconstruction is completed?

Do you always recommend treating breast cancer patients with getting reconstruction with their tissue expanders in place? Or is there a scenerio you w...

1 Answer available

How do you treat the chest wall after mastectomy with an expander?

Would you consider hypofractionation? If so,what dose? Would you consider a boost if there were close margins?

4 Answers available

Do you routinely offer PMRT for T3N0 breast cancer?

Although these patients are included in the Danish trials, Taghian et al. & Floyd et al. both showed ~ 7% LRR in this group of patients witho...

1 Answer available

When using EBRT to deliver APBI, what dose do you prescribe and to what volume?

NSABP B-39/RTOG 0413 prescribed a dose of 38.5 Gy using two fractions of 3.85 each daily, but prescribed to the ICRU 50 reference point dose (usually ...

1 Answer available

What is your IGRT strategy for prone breast radiation?

Do you use CBCT or kV images? Do you match to the breast or the chest wall?

2 Answers available

What volume would you treat after solitary axillary nodal recurrence after previous lumpectomy in a breast cancer patient without prior radiotherapy?

Is it necessary to irradiate the breast?

4 Answers available

Would you recommend observation for an early stage, low grade, ER+, pure tubular carcinoma of the breast after lumpectomy with negative margins for women younger than 65?

1 Answer available

Would you offer PMRT for cT2N0 triple negative breast cancer s/p NAC and mastectomy with residual disease and no positive lymph nodes?

Patient will receive adjuvant xeloda.

1 Answer available

What adverse pathological features would be an indication for WBI (whole breast irradiation) after a patient receives IORT for early breast cancer?

An ASTRO APBI update readers are warned “the combination of IORT and WBI should be used only with caution and limited to women with higher risk ...

1 Answer available

Are weekly port films or daily cone beams considered standard of care for 3D breast treatment?

NCCN states that daily imaging is discouraged but in practice many radiation oncologists are doing daily cone beam for non-IMRT breast

7 Answers available

Are there any known issues related to radiation in the setting of vitiligo?

There have been case series published on this topic (most recently, PMID:26853347) with reported depigmentation within the RT treatment field.

6 Answers available

Would you consider nodal irradiation alone (not irradiating chest wall) in an otherwise early stage breast cancer, cN0 patient but has a positive node from a SLN bx who is status post mastectomy?

2 Answers available

Would you recommend APBI in a suitable candidate if they have pre-existing breast implants?

Assume you have good margins and the cavity abuts the implant. Are there any specialized techniques that you would recommend?

1 Answer available

How do you approach an early stage breast cancer patient s/p BCS in which ECE is found on a positive sentinel node?

Do you advocate for completion ALND? If so, would you radiate the dissected axilla?

2 Answers available

How do you define your partial breast volumes when doing partial breast irradiation?

Do you use NRG/RTOG, IMPORT LOW, single institution data, or retrospective data?

1 Answer available

Would you recommend radiation planning with air tissue expanders in patients who will receive PMRT?

An example of an air expander is located at: https://www.airxpanders.com/index.php How do you ensure accurate dosimetry with the use of air ...

6 Answers available

Is post-mastectomy chest wall radiotherapy indicated for DCIS with very close (<1mm) or positive margins?

4 Answers available

Are connective tissue disorders a contraindication to breast radiation?

Specifically, any data or experience regarding Ehlers Danlos syndrome?

1 Answer available

Is multifocal disease an indication for RT in an elderly patient with early stage and otherwise favorable breast cancer?

2 Answers available

How does breast cancer histology affect your decision whether to omit radiation?

E.g. for lobular, etc.

1 Answer available

When considering post mastectomy radiation, do your recommendations change for a biopsy proven positive intramammary node in the axillary tail (prior to neoadjuvant chemotherapy) vs. positive axillary node?

How would your radiation targets change? There are not recommendations for intramammary nodes in guidelines.

1 Answer available

Would you recommend adjuvant radiotherapy with concurrent Ado-trastuzumab emtansine (T-DM1) in your breast cancer patients?

1 Answer available

What recommendations do you give to patients who ask about diet during breast cancer treatment?

2 Answers available

Is it acceptable to omit post-lumpectomy radiation in an elderly patient with recurrent, ipsilateral breast cancer but low risk features?

If the patient meets the CALGB criteria for the current cancer, are there situations where you would omit RT in a patient who has never had RT? What i...

1 Answer available

How would you treat an axillary presentation of a breast cancer in the absence of a breast primary?

Would you recommend mastectomy? What would you irradiate? What are your fields?

2 Answers available

When would you omit RT for pleomorphic LCIS?

Updated NCCN guidelines say there is no data to support radiation for pleomorphic LCIS. Previous discussion recommended radiation for LCIS https:...

1 Answer available

Can a lumpectomy boost be omitted in a cN0 triple negative breast cancer that has a complete response after neoadjuvant chemotherapy?

If planning standard fractionation, what factors would you consider in omitting a boost (ie age, LVSI, etc)?

3 Answers available

What criteria do you use to treat the supraclavicular region in women with T1-2 disease breast cancer and 1-3 positive lymph nodes?

1 Answer available

Are there local control and/or toxicity differences between multi-catheter interstitial versus balloon catheter techniques for APBI?

Which do you favor, if so?

1 Answer available

How do results from NSABP B-39 influence your practice for APBI compared to WBI in early stage breast cancer?

https://www.abstracts2view.com/sabcs18/view.php?nu=SABCS18L_568 Any concerns regarding toxicity with APBI?

1 Answer available

Would you offer regional nodal irradiation for cN1 breast cancer patients who undergo neoadjuvant chemotherapy and experience a complete nodal response?

Assume she refused enrollment on B51.

1 Answer available

Would you consider breast radiation in patients with atypical ductal hyperplasia bordering on low grade DCIS?

1 Answer available

Would you recommend a simultaneous integrated boost with hypofractionated whole breast radiation?

1 Answer available

How do you counsel your breast-cancer survivors about weight-loss/dietary modifications?

Do your recommendations differ if patients are pre or postmenopausal given the data?

3 Answers available

Would you recommend local therapy for a residual breast tumor after chemotherapy following CR of distant disease in a patient with metastatic disease?

What factors influence your recommendation?

1 Answer available

Are there any contraindications to treating early stage breast cancer with radiation in patients on rituximab?

If a patient is on rituximab for multiple sclerosis, do you recommend a particular fractionation to minimize chance of MS flare during treatment? If a...

1 Answer available

Does the presence of interstitial lung disease affect your recommendation for BCT vs mastectomy for early stage breast cancer?

Would you recommend a patient get mastectomy to avoid radiation? If treating a breast cancer patient with ILD, what lung dose constraint do you use?

1 Answer available

When do you consider neoadjuvant radiation for inflammatory breast cancer?

1 Answer available

In light of the AMAROS trial, how do you decide between ALND vs. axillary RT?

In particular, I have a patient who underwent lumpectomy for a T3 tumor with positive margins and 1/2 SLN+. She is now scheduled for mastectomy ...

5 Answers available

How do you counsel a patient with breast cancer and a rad50 mutation when deciding between lumpectomy and radiation vs mastectomy?

rad50 is a key DNA repair protein.

1 Answer available

Would you offer APBI in patients with a high Oncotype who are otherwise considered “suitable” per ASTRO guidelines?

What if the patient is refusing chemotherapy?

2 Answers available

How do you sequence follow up mammograms in patients undergoing breast cancer treatment?

If a patient is due for their yearly mammogram on the breast that has been diagnosed with cancer but is still undergoing active treatment (chemo or ra...

1 Answer available

Do you recommend matchline shifts when treating abutting photon and electron fields when treating the chestwall?

1 Answer available

Would you consider hormonal therapy and no RT in an elderly pt who developed a contralateral early stage, ER+ breast cancer while on Tamoxifen for previous breast cancer?

Hormonal therapy would not be tamoxifen.

2 Answers available

Would you recommend removal of pec muscle for a positive microscopic deep margin post mastectomy?

Would you recommend this for a focally +, diffusely +, grossly + margin? What would you expect local recurrence rate for diffusely (+) microscopic mar...

1 Answer available

Do you differ your PMRT treatment if a patient had a nipple sparing mastectomy?

Would you do anything different than usual regarding bolus, energies, skin dose desired for post-mastectomy chest wall radiation if a nipple-sparing m...

2 Answers available

Do you omit the breast boost in patients with lumpectomy bed near the nipple areolar complex?

Is there concern for increased risk of chronic nipple pain with NAC in the boost field?

1 Answer available

When giving a breast boost, what are indications for a photon breast boost?

At what energy of electrons would it be better to use photons? How many fields and what field angles should be used for photon boosts?&nbs...

2 Answers available

Would you treat bilateral synchronous breast cancers in prone position?

What techniques have you used to evaluate for field overlap given the different setups? We have used a thick wire placed at midline during the verific...

1 Answer available

Would you recommend hypofractionated treatment for early stage, bilateral breast cancers?

Assume each primary meets ASTRO 2018 guidelines

3 Answers available

Would you consider hypofractionated weekly whole breast irradiation for early stage breast cancer?

Do you consider this regimen based on the 10 year results of the UK FAST trial?

3 Answers available

Why is it more preferable to perform SLNB after neoadjuvant systemic chemotherapy versus before therapy?

Per NCCN guidelines, SLNB after neoadjuvant chemotherapy is preferred.

1 Answer available

Would you consider APBI in a patient <50 years of age?

Assume patient is otherwise a suitable candidate.

1 Answer available

Are there situations in which you would definitely recommend radiation in an elderly patient with ER+, early stage breast cancer?

Would multifocality, multicentricity, LVSI, N1mi, etc affect your decision making?

6 Answers available

How would you re-irradiate a breast recurrence in a patient treated with prior whole breast radiotherapy?

Assume patient has refused surgery and additional systemic therapy.

1 Answer available

Would you initiate radiation before chemotherapy for the treatment of early stage breast cancer?

Results for oncotype Dx are not always available readily.

6 Answers available

How would you manage an elderly patient with metastatic breast cancer with locally advanced bilateral primaries?

Assume the patient has bone only metastses and will be on hormonal therapy

1 Answer available

Would you recommend radiation for an unresectable chest wall recurrence after two prior courses of radiation?

2 Answers available

Do you consider dermal invasion an indication for PMRT in the absence of other risk factors?

If a patient has early stage disease with peau d'orange but does not meet criteria for inflammatory breast cancer, is PMRT indicated?

4 Answers available

How does LVI affect PMRT decision in a node positive patient?

Should LVI be considered present in a patient with positive nodes? MSKCC showed that LVI is a risk for LRR with 1-3 positive nodes...

2 Answers available

Would you offer radiation to the contralateral breast if after neo-adjuvant chemo and prophylactic contralateral mastectomy yielded ITC only in a single lymph node and no breast primary?

Would you treat both chest walls at the same time? What fields would you use for the contralateral side: chest wall and lymph nodes? or just lym...

2 Answers available

Would you recommend modification of radiation dose or fields in a breast cancer patient in which radiation is recommended who has had prior total body irradation?

1 Answer available

Would you recommend adjuvant radiation to the breast for low grade adenosquamous carcinoma after lumpectomy?

1 Answer available

What is your approach for PMRT when the patient has a DIEP flap?

2 Answers available

Are there any treatment related considerations in a patient with HIV who is on antiretroviral therapy and receiving adjuvant radiation for breast cancer treatment?

What if CD4 count was low?

1 Answer available

What strategies to you use for large breasted women receiving whole breast radiation?

Particularly for patients too large for prone breast treatment, do you use a breast immobilization device or bra? Do you change your fractionat...

2 Answers available

Would you consider radiation to the axillary lymph nodes ONLY (omitting chest wall) for patients with 1-3 axillary LNs who would otherwise not receive post-mastectomy radiation (T1-2, clear margins etc) when these patients have or will undergo breast reconstruction?

Several surgeons have asked this to reduce the time to reconstruction, complications like contracture, and the possibility of re-operation/failure of ...

3 Answers available

How would you manage an axillary lymph node only recurrence after prior mastectomy, chemotherapy and hormone therapy?

Assume your patient did not receive radiation upfront and they had an axillary dissection due to recurrence. Would you recommend radiation? What would...

1 Answer available

Would you offer PMRT to an ER/PR positive HER2 amplified early stage (node negative) breast cancer patient found to have less than pCR to neoadjuvant TCHP?

1 Answer available

Would you recommend observation in an elderly patient with an ER positive, early stage breast cancer who has a high risk Oncotype Dx score?

Would your decision change if the patient is getting chemotherapy and hormonal therapy?

2 Answers available

Would you recommend PMRT in a patient with dermal invasion as the sole adverse feature after a skin sparing mastectomy for an early stage breast cancer?

In the absence of epidermal invasion and absence of dermal lymphatic invasion (DLI)

1 Answer available

What is your strategy for image surveillance for occult breast cancer after treatment?

1 Answer available

How do you manage focal DCIS in mammoplasty specimen?

Any consideration on standard vs hypofractionation?

1 Answer available

Would you ever recommend PMRT to the chest wall alone without nodal radiation for invasive or in situ breast disease?

4 Answers available

For an early stage, estrogen receptor positive breast cancer in an elderly patient, would you recommend: hormonal therapy alone, radiation alone or both?

There has been shifting concerns with medication side effects (such as osteoporosis, blood clots), duration, and potential non-compliance.

4 Answers available

How would you treat a patient who had a previous mastectomy for an early stage breast cancer (without XRT) and then develops an isolated axillary recurrence and undergoes ALND?

What volumes and dose would you treat? Would you treat the regional nodes alone (including IMN)? Would you treat the chest wall?

2 Answers available

How do you counsel an early stage breast cancer patient with lupus regarding decisions on radiation?

3 Answers available

How do you manage fatigue in women receiving chemotherapy/hormonal/radiation therapy for breast cancer?

3 Answers available

Would you recommend ALND or sentinel node re-mapping in a patient with recurrent breast cancer of the areola complex who had previous nipple-sparing mastectomy and SLNB and no previous radiation?

Assume workup is otherwise negative and she will get XRT.

3 Answers available

How would you treat a large-cell neuroendocrine carcinoma of the breast with bulky axillary involvement with good response to neoadjuvant chemo followed by mastectomy/ALND?

Would you consider traditional breast doses or higher? Would you consider treating only the axilla if the mastectomy specimen showed widely-negative m...

2 Answers available

How do you counsel patients on multivitamin use during therapy?

2 Answers available

How do you approach an AVL (atypical vascular lesion) of the breast?

1 Answer available

When do you recommend endocrine therapy for chemoprevention in women with high risk benign breast lesions?

1 Answer available

What dose do you try to keep the contralateral breast when treating a PMRT inflammatory breast cancer that is extending across midline?

What techniques would you use to help meet that constraint?

2 Answers available

How do you manage sexual dysfunction in women receiving ovarian suppression for breast cancer?

3 Answers available

Should axillary imaging be routinely performed in all patients with a new diagnosis of breast cancer?

1 Answer available

What fractionation would you recommend in a patient with recurrent early stage breast cancer who has had prior lumpectomy and IORT and refuses mastectomy?

1 Answer available

Can you treat the regional lymphatics when using a prone technique for treating the whole breast?

If so, what is your technique?

1 Answer available

Will the recent publication of the MA.20 and EORTC 22922 studies in NEJM, showing no survival advantage from regional nodal irradiation in early-stage breast cancer patient following surgery, change your standard of care for these patients?

How much will you weigh the demonstrated disease-free survival, including distant disease-free survival, in your recommendations?

5 Answers available

How would you advise a woman who had a full axillary lymph node dissection on the risk of lymphedema with mountain climbing?

I have a patient who will be climbing to the base camp of Mount Everest. Does a climb to 15,000 feet increase her risk? Should she wear a compression ...

1 Answer available

What is the maximum V20 on ipsilateral lung that can be safely accepted for 3 or 4-field breast plans?

V20 of 30% can be hard to attain if IMs are being treated.

3 Answers available

Is ALND required in all patient with clinically positive axillary nodes?

1 Answer available

Would you recommend axillary dissection for a patient with a clinically positive SCV or IMN node, who has a clinical CR to neoadjuvant chemo, but a positive SLNB?

Does it make sense to resect only the axillary nodes, but not the other involved nodal regions? Regional nodal radiation will be given.

3 Answers available

How do you explain the risks and benefits of palliative radiation therapy to patients with fungating breast masses?

Patients are understandably concerned about the risks and benefits of radiation to an oozing, bleeding, ulcerated breast.

2 Answers available

Would you consider APBI in an otherwise-suitable patient who has ITC in a sentinel lymph node?

1 Answer available

Does the location of tissue expander and implant (pre-pectoral vs post-pectoral) have any impact on outcomes in patients treated with postmastectomy radiation?

1 Answer available

Would you ever treat the internal mammary lymph nodes in a high risk patient who is axillary sentinel lymph node negative?

What factors would you use to determine? Age, triple negative, LVSI, etc?

1 Answer available

Would you recommend APBI in an otherwise suitable candidate who is undergoing chemotherapy?

The patient will be planned using IMRT and fiducial placement.

1 Answer available

When do you hold radiation for moist desqumation to recover when treating breast cancer?

How significant does the moist desquamation need to be? Does the length of tretment remaining ( i.e. 1 v. 3 weeks) or use of medication effect your de...

2 Answers available

Do you ever consider local therapy to oligometastatic hormone-receptor positive breast cancer?

3 Answers available

What dose objectives and constraints do you use for hypofractionateed whole breast irradiation?

1 Answer available

Would you ever recommend a breast boost using BID fractionation due to patient scheduling?

What if this was an electron vs photon boost? What fractionation scheme would you use?

3 Answers available

What is the role of neoadjuvant breast radiation in patients with triple negative breast cancer progressing on AC-T?

Pt clinically has inflammatory breast cancer making mastectomy a poor option.

1 Answer available

When would you add an extra radiation dose to compensate for treatment breaks?

Apart from H&N SCC, are there times where adding an extra dose of radiation due to a tx break is appropriate? Is there a decent equatio...

1 Answer available

When is it necessary to boost the chest wall scar post-mastectomy?

3 Answers available

Is PMRT now considered the standard of care in women with 1-3 positive axillary lymph nodes?

Has the publication of the recent EBCTCG metaanalysis changed your practice?

5 Answers available

Would you consider catheter-based APBI in the setting of a recurrent Stage I breast cancer in a patient who has received whole breast radiotherapy and is refusing mastectomy?

If so, what dosing amd fractionation would you use?

1 Answer available

Do you hold palbociclib (or another CDK4/6 inhibitor) in a patient with metastatic HR+ breast cancer while receiving palliative radiation?

4 Answers available

How would you treat a high grade sarcoma of the breast?

Is breast conserving surgery followed by radiation therapy an option?

1 Answer available

How do you sequence radiation and capecitabine in breast cancer patients receiving adjuvant capecitabine for residual disease after neoadjuvant chemotherapy?

It is not clear from CREATE-X whether radiation was before or after capecitabine. Is there a preferred approach?

3 Answers available

What margins (CTV and PTV) do you use for boosting breast lumpectomy cavity?

1 Answer available

How long after definitive treatment is it reasonable to consider reconstruction for a woman with inflammatory breast cancer?

Inflammatory breast cancer is a contraindication for immediate reconstruction at the time of surgery, but is there a disease free interval after all t...

1 Answer available

Would you recommend PMRT in a male patient with a T2N0 breast cancer?

1 Answer available

Do you recommend resection for positive anterior or posterior margins in a patient s/p mastectomy if the surgeon says they took all the breast tissue anteriorly to the skin or posteriorly to the fascia?

Would you recommend PMRT for these patients if they did not undergo resection? Would you boost if they had other indications for PMRT?

1 Answer available

Would you re-irradiate the axilla after a resection for an isolated axilla recurrence in a breast cancer patient who had prior radiation to the breast and axilla?

If so, what fields would you treat? What dose/fractionation would you recommend?

2 Answers available

Do you treat early stage breast cancer patients with hypofractionation in the prone position?

2 Answers available

How do you manage early stage breast cancer in patients who can not have a surgery?

1 Answer available

Do you recommend hypofractionated/Canadian fractionation for in-situ ductal cancer?

What about lobular carcinoma?

5 Answers available

How do you counsel young and educated patients with non-metastatic breast cancer who choose non-proven "natural" treatments over standard therapy?

What do you do/say when a discussion of evidence-based information doesn't convince a patient that this is her best chance of cure? Some patients even...

5 Answers available

How do you treat women who have breast-conserving surgery with positive sentinel node/s and no axillary dissection?

After the publication of ACOSOG Z11 we are seeing these patients in increasing numbers.

7 Answers available

Would you recommend hypofractionation in breast cancer patients who had partial mastectomy with significant oncoplasty?

1 Answer available

What is the rate of a cardiac events that you quote to a patient with preexisting heart disease going on trastuzumab for metastatic Her2+ breast cancer?

How does it vary for patients with a history of hypertension, diabetes, CHF, and coronary artery disease?

1 Answer available

In which patients do you omit a boost following whole breast irradiation?

Do patients > 60 years old with no high risk features have any significant benefit? Has the recent update of the EORTC boost trial affected your pr...

3 Answers available

Is there any role for post-mastectomy radiation in the setting of N1mic axillary disease?

What if it was found on SLNB and no axillary dissection was performed? Any risk factors that would make you consider RNI vs CW only vs observation?

1 Answer available

Would you hypofractionate breast cancer patients with >25 cm separation?

Do you boost when employing this regimen?

3 Answers available

Is your decision to treat with hypofractionated radiation impacted by histology, ie lobular vs ductal cancers?

What about tumor subtype, ie luminal A/B, Her2 positive, triple negative?

2 Answers available

When treating an intact whole breast with hypofractionated radiation, how do you approach boost dosing in the case of a close margin?

In a setting of standard fractionation, we would sometimes consider going to 66Gy total dose to the boost cavity, so how would you "translate" this to...

4 Answers available

What technique, total dose, and fractionation do you use for DCIS following lumpectomy with <2 mm negative margins which are not re-excised?

The recently published SSO/ASTRO/ASCO consensus guideline on DCIS states that "a 2 mm margin minimizes the risk of IBTR compared with smalle...

3 Answers available

What total dose do you use for a close and positive breast cancer margin that cannot be re-excised?

For conventional fractionation, should one increase total dose above 60 Gy for either close or positive margin (invasive or DCIS). What about for acce...

2 Answers available

Do you use a tumor-bed boost following whole breast irradiation for patients with DCIS?

When would you omit or include a boost for DCIS after whole breat irradiation?

4 Answers available

When utilizing the Canadian Regimen of 4256cgy/16 fxn- what boost dose and fractionation are you using?

5 Answers available

Does the molecular subtype of breast cancer influence your decision to give hypofractionated radiotherapy?

Should hypofractionation be avoided in triple negative disease?

4 Answers available

Do you offer hypofractionated accelerated whole breast radiation therapy for women receiving trastuzumab during RT, particularly those with left sided primaries?

In START B ~ 23 % of women received some form of cytotoxic chemotherapy, and the trial was conducted in the trastuzumab era, but there is no ment...

2 Answers available

Do you avoid hypofractionated regimen for Grade 3 early stage breast cancer?

The Canadian trial showed conventional fractionation might be better in the Grade 3 subset, but this was not shown in the START A/B update. What can e...

5 Answers available

What dose-fractionation regimen do you prefer when treating with hypofractionated whole breast radiation therapy without a boost for early stage breast cancer?

3 Answers available

Is there an age cutoff you use to determine when you will offer standard vs hypofractionated breast radiation in early stage breast cancer?

Do you offer hypofractionation to younger women?

5 Answers available

How would you treat a patient who had bilateral mastectomies for a bilateral squamous cell carcinoma of the breast with a positive lymph node?

How does your approach differ due to squamous cell carcinoma histology? What are your radiation fields?

1 Answer available

How do you approach breast cancer treatment planning for patients with tissue expanders that have magnetic valves or metal ports?

What dose calculation algorithm to you utilize (eg AAA, Acuros, etc)? Do you prefer a particular algorithm for certain sites? Do you take in...

1 Answer available

What is your approach to young healthy women with locally advanced breast cancer and biopsy-proven low cervical lymph nodes?

Would you treat this as a locally advanced breast cancer and offer surgery, radiation, and systemic therapy? Does your management change depending on ...

2 Answers available

Should one perform a sentinel node biopsy in a clinically negative axilla prior to neoadjuvant chemotherapy?

NSABP B51 and B52 specifically prohibit this.

2 Answers available

Do you always use a bolus when treating with postmastectomy radiotherapy?

I trained at a place where use of a bolus for chest wall irradiation PMRT was standard practice, but this is not so at my practice right now. As...

3 Answers available

How would you treat recurrent unresectable skin nodules on the chest wall after mastectomy and axillary lymph node dissection?

Assume no history of radiation, no evidence of distant disease and no nodal disease on dissection. Would you treat the chest wall or the&nbs...

5 Answers available

What role, if any, should Ki-67 play in decision making about the role of adjuvant radiotherapy in patients who meet CALGB 9343 entry criteria?

Would a high result give you pause about omission of RT? If yes what level is sufficiently high?

1 Answer available

What is the complication profile of subpectoral versus sublgandular implants after PMRT?

What data do you quote patients with implants after PMRT?

1 Answer available

Are there any situations where you would not offer SBRT for an oligometastatic bone lesion from breast cancer?

Is the dose fractionation used in BR-001 (10Gyx3) appropriate for all osseous locations, for example humeral head metastases?

1 Answer available

What dose would you treat a patient to for a positive deep skeletal muscle margin after mastectomy who is not a candidate for re-resection?

1 Answer available

Do you take any precautions in planning PMRT for patients who had taxane-induced pneumonitis?

Assuming the patient has N2-3 disease, would you consider omitting IMN? What other techniques would you consider to limit lung exposure?

1 Answer available

Based on data from CREATE-X/JBCRG-04, would you consider adjuvant capecitabine in breast cancer patients treated with neoadjuvant chemotherapy who do not achieve a pCR?

http://www.nejm.org/doi/full/10.1056/NEJMoa1612645?rss=searchAndBrowse&#article_abstract If so, how do you sequence it with adjuvant radiotherapy...

2 Answers available

What dose regimen do you use when a women with inflammatory breast cancer is not responding to chemotherapy and needs radiation prior to surgery?

2 Answers available

Would you recommend PMRT in a patient with early stage breast cancer who has multicentric disease and close margins?

1 Answer available

How are you using the data on cardiac morbidity in regards to the LV-V5 in breast cancer patients?

Is there a dose constraint you are using for LV-V5? https://www.ncbi.nlm.nih.gov/pubmed/28095159?dopt=Abstract

1 Answer available

For breast cancer with occult primary, do you favor radiation therapy or mastectomy for local management?

At what point would you decide to forego local control managment (RT or mastectomy) in favor of chemotherapy alone?

1 Answer available

Do you intentionally modify your breast cancer treatment plans for those on chronic immunosuppression to avoid secondary cancers?

This is in regards to the risk of secondary cancers after radiation therapy or cytotoxic chemotherapy (such as anthracyclines) in an immunosuppre...

1 Answer available

Would you recommend RNI for a triple negative cancer s/p lumpectomy and ALND with low LN positivity rate?

Assume patient had 15 nodes removed. What if 1 or 2 nodes were positive?

2 Answers available

Should regional nodes be included in whole breast RT for a favorable pT3N0 breast cancer after lumpectomy and SLNB?

Would patient age factor into your decision, such as a patient <30 or 40? If you would not give RNI for a favorable pT3N0, are there other risk fac...

1 Answer available

Would you recommend post lumpectomy RT in an elderly woman with a T1N0M0 stage breast cancer ER/PR/HER2 positive?

CALGB 9343 included ER positive patients but did not separate them out based on herceptin status. Does the study help inform their risk?

1 Answer available

How would you treat the axilla if a breast cancer patient had cN1 disease in the axilla but after neoadjuvant chemo the SLNB revealed no positive nodes and the clip placed in the axilla was not found?

1 Answer available

How would you counsel a patient who will undergo breast irradiation in which a large port wine stain is overlying the breast?

Should the patient be counseled to anticipate a worse skin reaction than normal?

2 Answers available

How do you treat an early stage breast cancer with cN0 but could not undergo a SLNB?

Would you recommend any imaging of the axilla before lumpectomy? Would you recommend standard breast fields vs high tangents to cover the lo...

1 Answer available

If a SNB is positive after neoadjuvant chemo and mastectomy, should an axillary dissection be performed or xrt given to all?

3 Answers available

How would you treat a biopsy proven isolated internal mammary node recurrence one year after a mastectomy and chemotherapy?

Assume the patient had no radiation, what would your volumes be? Would you recommend radiation if the patient had whole breast/chest wall radiati...

1 Answer available

How does treatment management change with a positive intramammary lymph node in the setting of a negative axilla, with the inclusion of these as N1 node in the AJCC 8th edition?

1 Answer available

Would you boost a resected axilla if extra-nodal extension is found in a patient with breast cancer?

What are your volumes? What if the lymph node area was not clipped?

1 Answer available

For women receiving breast RT who develop a severe skin reaction during treatment, what is your threshold for giving a treatment break?

When do you institute a treatment break for skin reaction for patients who receive breast radiation?

1 Answer available

Would you treat your left sided breast cancer patients with DIBH (deep inspiration breath hold) and IMRT when the target includes regional lymph nodes?

Do concerns about matching with 3D plans justify IMRT?

2 Answers available

Would you recommend APBI in an otherwise "suitable" patient who has had a previous history of estrogen replacement therapy prior to early stage breast cancer diagnosis?

There is anecdotal concern regarding history of estrogen replacement therapy causing stimulation of breast tissue and therefore potentially increased ...

1 Answer available

Would you offer PMRT after NAC in a boderline patient with a pCR based on suspicious pre-chemotherapy IM nodes?

In other words, if there are borderline indications for PMRT (ex initial T3N0 or T2N1 disease) with a pCR, would the suspicious IM nodes lead you to o...

1 Answer available

Would you consider adjuvant RT in an elderly patient with a T1N0 ER+ breast cancer who initially proceeds with endocrine therapy alone and is unable to tolerate it?

What is the maximal amount of time you would allow between the surgery the start of adjuvant RT? What other factors would you consider when deciding w...

2 Answers available

When do you recommend PMRT for individuals with spindle cell carcinoma of the breast?

Do you use the typical indications for PMRT (nodal status, size of primary, LVSI, age, etc)? Or, do you recommended PMRT more frequently (...

1 Answer available

Is post-mastectomy radiation required in patients with cT2N1 breast cancer who undergo neoadjuvant chemotherapy and are then found to have negative lymph nodes at the time of mastectomy?

1 Answer available

What is the sensitivity of SLNB after neoadjuvant chemotherapy for cN0 patients?

When would you recommend that SLNB be performed prior to neoadjuvant chemotherapy? When would you recommend additional staging (completion axillary di...

1 Answer available

What type of IGRT do you use for external beam partial breast irradiation?

5 Answers available

Would you offer a patient over 70 years old with early stage, favorable breast cancer adjuvant whole breast radiation if her sentinel node biopsy shows a single node with isolated tumor cell (ITC)?

What fields would you treat?

1 Answer available

What volume would you treat for an isolated axillary recurrence after BCS and whole breast RT who have resection of the recurrent disease?

Would you treat the regional nodes alone (not previously irradiated) or would you also re-treat the breast/chest wall?

3 Answers available

Would you treat a patient with an early stage favorable breast cancer who has synchronous advanced (or metastatic) NSCLC?

What factors would help you make your decision? (Age, genetics of lung or breast cancer, triple negative, LVSI, T2, etc?)

1 Answer available

What is your strategy and evidence to use hyperthermia and/or chemotherapy with radiation for recurrent breast cancer?

2 Answers available

What are your considerations in choosing partial breast irradiation versus external beam hypofractionated whole breast RT for early stage breast cancer?

2 Answers available

Would you recommend BCS and adjuvant radiation for early stage multicentric breast cancer?

What would you consider when thinking about your boost?

1 Answer available

How would you advise your patient about starting adjuvant breast radiation who has a planned vacation?

Would you rather they delay the start of treatment so that it was >3 months from date of surgery or have a break of several weeks during XRT? Assum...

1 Answer available

Would you treat the chest wall alone in a patient that had a previous prophylactic mastectomy and later developed an early stage breast cancer pT1-2N0 after a "lumpectomy"?

1 Answer available

How does radiation to the breast in a lactating woman affect milk production?

And does the fact that the breast is lactating affect radiation toxicity in anyway?

2 Answers available

Is pectoralis muscle invasion an indication for post-mastectomy radiation (PMRT) for an otherwise early stage, node negative breast cancer with clear margins?

3 Answers available

Would you give PMRT to a young woman with a T1-2 breast cancer with a micromet on SLNB?

What factors would help aid your decision?

2 Answers available

What is the maximum acceptable hot spot for hypofractionation breast?

For hypofrac breast patient (such as 40 Gy in 15 fractions), what is the maximum hot spot that you will accept anywhere in the breast? 107-8%? 1...

1 Answer available

What treatment fields do you use for N1mi breast cancer after lumpectomy/SLNB?

Comprehensice RNI? High tangents? Whole breast only? Does ER/PR/Her2 status influence your decision?

1 Answer available

Is superficial underdosing of hypofractionated breast RT acceptable in patients with a large breast separation?

When trying to eliminate dose heterogeneity during field in field planning for hypofractionated breast radiation with a large separation, the resultin...

1 Answer available

For patients demonstrating ypN1 disease on SLNB following neoadjuvant chemotherapy, is it reasonable to proceed with regional RT in lieu of AxLND outside of the ALLIANCE A011202 trial?

1 Answer available

If a patient has a history of lumpectomy and adjuvant radiation, and then develops an in-breast recurrence s/p mastectomy with breast only disease and no nodal disease, would you re-irradiate the chest wall?

Would you include the regional nodes?

2 Answers available

In which Her2+ breast cancer patients would you recommend extended adjuvant therapy with neratinib?

The FDA recently approved neratinib based on data from the ExteNET trial; however, benefit appears modest and the risk of toxicity is not low.

1 Answer available

Would you offer breast conservation or PMRT (if clinically warranted) to someone with breast cancer in the context of Li Fraumeni syndrome?

1 Answer available

When treating with high tangents, do you use conventional fractionation or hypofractionation?

1 Answer available

Would you offer whole breast RT in an elderly patient with early stage breast cancer with EIC?

If the patient meets CALGB criteria but has EIC would you lean towards giving RT? What other factors would lead you to give whole breast RT an elderly...

3 Answers available

Is breast conservation therapy appropriate for mutation carriers?

Is the risk of IBRT any greater than in non mutation carriers?

2 Answers available

What is your strategy for managing radiation dermatitis in breast cancer in the prophylactic, erythema/dry desquamation, and moist desquamation stages?

What agents have you found helpful? What agents have been proven to be effective/non-effective?

4 Answers available

Are there any cases for which you would limit the dose to the scapula or ribs when treating the breast/chest wall and regional nodes?

1 Answer available

What is your practice regarding axillary isolated recurrence after surgery when a patient received previous whole breast radiation?

Does neoadjuvant chemotherapy with complete response in the axilla alter your management preferences?

2 Answers available

Would you consider omitting breast radiation in a male with early stage breast cancer who has undergone BCT?

If a male has early stage breast cancer and would otherwise meet criteria for the CALGB or PRIME II trials, would omission of radiation be an option? ...

1 Answer available

What dose-fractionation schedule do you utilize to treat a locally advanced, symptomatic breast mass in a patient with metastatic breast cancer?

1 Answer available

For patients who are incidentally found to have pT1a invasive breast cancer on excision for presumed atypia/DCIS without a sentinel lymph node biopsy, will you irradiate without the SLNB being performed?

How does patient age, grade, histology (IDC vs. ILC) and ER status affect your recommendations

1 Answer available

Would you consider PMRT in patients with clinically node negative breast cancer found to have micrometastatic nodal disease after neoadjuvant chemotherapy?

Would it matter if the patient did or did not have a pathologic CR in the breast?

3 Answers available

What do you recommend to a patient who has biopsy positive DCIS or invasive carcinoma and at time of lumpectomy the pathology is benign (assuming biopsy pathology and post surgical tumor needle localization verified)?

1 Answer available

Do you try to cover the entire mastectomy scar with PMRT even if it crosses over midline to contralateral side?

Any recommendations on technique?

2 Answers available

How does your treatment of lymph nodes change for a breast cancer with limited (<2mm) vs more extensive ECE?

1 Answer available

When treating the regional nodes, what factors cause you to treat the lower axilla?

e.g. how does the tumor burden on axillary dissection, sentinel biopsy only, extracapuslar extension, and the size of hte metastasis play into your de...

1 Answer available

Does the upstaging of breast cancer based on grade and hormone receptor status in AJCC 8 change your treatment recommendations?

Is it still acceptable to deliver hypofractionation for what was previously a Stage I TN breast cancer, now Stage IIIA? Should RNI be considered? Or e...

1 Answer available

What is your approach to left sided PMRT in patients with on-going cardiac issues (ie. cardiomyopathy, heart failure, coronary heart disease)?

How do you best counsel their radiation risks?

4 Answers available

Would obtaining a breast MRI for patients going to be treated with APBI be beneficial?

1 Answer available

Would you treat the supraclavicular field and IMNs for a patient with cT3N0 breast cancer who has a complete response following neoadjuvant chemotherapy?

The subquestion can be "Ex if you are offering PMRT for reasons like young age and Her2+?

1 Answer available

Do you recommend PMRT and if so, do you treat the regional nodes, in patients who are cT4N0 (non-inflammatory) treated with neoadjuvant chemotherapy who have a pCR at the time of mastectomy?

1 Answer available

What do you do for patients who require radiation for breast cancer (either post-lumpectomy or post-mastectomy) but who have a pacemaker on the ipsilateral side?

Do you attempt to have the pacemaker moved? If the patient is non-dependent, would you ever treat with the pacemaker in field?

2 Answers available

How does implant breast reconstruction/augmentation at the time of lumpectomy affect your adjuvant radiotherapy approach?

Do the same concerns as post-mastectomy radiation of implants apply? There are some small case series' (https://www.ncbi.nlm.nih.gov/pubmed/21346535 ...

1 Answer available

Would especially young age (eg 20's) influence your recommendation for breast conservation vs mastectomy in an early stage breast cancer?

4 Answers available

How do you counsel women with a history of breast cancer who have dense breasts, with regards to mammography screening?

Is there a role for routine use of additional or alternative imaging modalities for these patients, such as tomosynthesis, MRI, or ultrasound? I...

2 Answers available

When do you use IMRT in breast radiotherapy?

Do you also use DIBH in these cases?

1 Answer available

How do you manage anticoagulation for patients with DVT/PE who have brain metastases?

Some medical oncologists tend to hold anticoagulation in patients who develop brain metastases for fear of causing intracranial hemorrhage. Is t...

3 Answers available

Would you offer radiation to an elderly patient with DCIS who would otherwise not meet criteria for RTOG 9804?

E.g. someone with high grade and/or >2.5cm disease? If we use age as a cutoff in invasive disease to omit adjuvant radiation based on the...

2 Answers available

Do you ever withhold adjuvant RT after BCS in older women with stage I triple positive/Luminal-Her2 subtype breast cancers?

Her2 status was not evaluated as part of the PRIME 2 or CALGB trials and luminal Her2 patients likely represent a small minority of those enrolle...

1 Answer available

How do you manage patients who need radiation for synchronous locally advanced head and neck cancer and locally advanced breast cancer?

Would you recommend a mastectomy for her breast cancer in attempts to avoid RT? If the patient undergoes a lumpectomy or needs PMRT, would you a...

2 Answers available

How would you manage a patient with a rapidly growing, clinically localized breast cancer who is medically inoperable?

1 Answer available

If a patient has a mediport within the radiation field, will you insist the patient have it removed prior to radiation?

If not, are there certain dose constraints one considers?

3 Answers available

Do you ever use molecular assays such as Oncotype to modify your recommendations for withholding RT after lumpectomy in invasive breast cancer?

1 Answer available

Is it safe to offer breast/chest wall radiotherapy while a patient is receiving Perjeta?

3 Answers available

Do you recommend omitting radiation therapy in young women with favorable DCIS?

How would you approach a young woman (under the age of 50) with DCIS with favorable disease (ER+, low grade, small size <5mm, negative margins)?

4 Answers available

Does the presence of multifocal disease impact your decision on whether or not to recommend post-mastectomy radiation?

Is it a factor you consider, especially in borderline cases?

3 Answers available

Are your criteria for PMRT in men different than your criteria for PMRT in women?

For instance, are you more likely to offer PMRT to a man who is node negative but with several high risk features such as high grade, LVI, high oncoty...

2 Answers available

Are there situations for which you consider concurrent chemoradiation for breast cancer patients?

This is rarely done, but recently came up in a tumor board discussion. Which chemotherapy would you consider using, and when?

3 Answers available

What strategies do you use for dose escalation when irradiating patients with inflammatory breast cancer?

Do you ever use BID fractionation? What patient factors do you use to individualize the treatment?

1 Answer available

Do you routinely perform an axillary ultrasound in women with newly diagnosed breast cancer without palpable axillary nodes?

If no, in what patients should axillary ultrasounds be performed?

1 Answer available

What is the best management of early stage breast cancer in patients with a minimal life expectancy (<10yrs)?

Would your management change if the patient had extensive DCIS?

2 Answers available

What margin do you give around the internal mammary vessels when treating IMN nodes for breast cancer?

How many intercostal spaces do you include? Do you vary these parameters based on the disease characteristics?

1 Answer available

Should pre-pectoral implants be avoided for reconstruction in breast cancer patients out of concern that it may mask local recurrences?

1 Answer available

In what setting is PMRT indicated for T1-2N0 breast cancer?

Is there a practical way to quanitfy risk of LRR in patients with T1-2 N0 with multiple high risk factors in such as multifocal disease, high grade, L...

4 Answers available

When treating patients with hypofractionated radiation to the breast in 16 fractions do you typically treat 4 or 5 days a week?

1 Answer available

When treating patients with whole breast RT with a sequential boost, what technique to you use for the boost when treating patients prone for whole breast irradiation?

1 Answer available

In patients with 3 or more positive sentinel lymph nodes who get a SLNB only, do you advocate for an ALND even if you are planning to treat their regional nodes regardless?

These patients were not eligible for Z0011 and represents less than 5% of the patient population in AMAROS. Thus, can you apply these two trials to ju...

1 Answer available

How do you apply the concept of a lumpectomy bed boost in the setting of oncoplastic surgery?

After multiple adjacent tissue transfers it is difficult to define a "tumor bed" with oncoplastic surgery. Surgical clips are often useful ...

4 Answers available

How would you approach a patient with metastatic breast cancer with extensive skin involvement?

Would you send the patient to a surgeon for consideration of a mastectomy? Would you then consider post mastectomy radiation when the risk of re...

1 Answer available

Is it safe to hypofractionate for whole breast RT in patients with a BRCA 1/2 or CHEK2 mutation to chose to have breast conservation for early stage breast cancer or DCIS?

2 Answers available

What is the best treatment management for a metaplastic carcinoma of the breast (such as adenosquamous)?

What are indications for adjuvant radiation for a early stage well differentiated adenosquamous carcinoma of the breast? What is the best radiation th...

1 Answer available

What dose would you use to treat an unresectable axillary breast cancer recurrence in a patient who has not previously received radiation therapy?

2 Answers available

Do you offer post-mastectomy radiation for invasive lobular carcinomas?

What factors in particular guide your recommendation of PMRT for invasive lobular carcinoma?

1 Answer available

How do you manage moist desquamation when treating breast cancer?

1 Answer available

Is it necessary to cover the drain sites during post-mastectomy radiation?

Would your management change if including the drain sites requiree treating more lung or adding separate electron fields?

1 Answer available

After chemotherapy for early and locally advanced breast cancer, how long do you advise women to wait before attempting to conceive?

Does your recommendation change depending on the agents they received?

1 Answer available

When would you offer PMRT to a patient after prior TNI for lymphoma?

What factors do you consider when offering PMRT? Would you change your dose/fx and/or field size?

1 Answer available

After cryoablation for early breast cancer are there any particular considerations to take when planning adjuvant RT?

1 Answer available

In a patient with ER+/HER2- breast cancer, do you ever use Oncotype testing to assist in decision-making regarding adjuvant chemotherapy when the tumor size is less than 0.5 cm, or when there are positive lymph nodes?

1 Answer available

When do you recommend a breast MRI for breast cancer surveillance?

Would you recommend it for a mammographically occult primary or if the patient had dense breasts? What if a high risk patient decides not to hav...

1 Answer available

In women with cN0 breast cancer who receive neoadjuvant chemotherapy due to other high-risk features, how does the finding of treatment effect in a post-chemo sentinel lymph node affect your radiation recommendations?

Women with cN1 disease at diagnosis who are ypN0 after neoadjuvant chemo can be randomized on NSABP B-51, but not those with cN0 disease and treatment...

1 Answer available

Would you ever boost the lumpectomy cavity and the scar after whole breast RT?

What about in cases of a tunneled lumpectomy cavity using a circumareolar incision?

1 Answer available

Is hypofractionation ever appropriate in women with early stage breast cancer and latent lupus who have never experienced skin symptoms in their lifetime?

Do you always stick with a conventional fracionation, or in some cases, are you comfortable hypofractionating? Do you ever use a wait and see approach...

1 Answer available

Does finding a positive surgical margin containing pleomorphic LCIS in a patient with early-stage invasive ductal carcinoma of the breast affect your management in regards to breast conservation therapy?

Would you recommend re-excision of a positive margin containing only pleomorphic LCIS prior to radiation for BCS? Does the presence of ...

2 Answers available

What options would you present to an otherwise healthy patient with early-stage breast cancer who absolutely refuses surgery?

Are there any data to support whole breast RT, SBRT, or cryoablation?

1 Answer available

Are there any circumstances in which you would treat only the lymph nodes and omit the chest wall for PMRT?

1 Answer available

Can close surveillance be used to manage an intracystic papillary carcinoma that is associated with a small amount of low grade DCIS?

What factors do you consider when adding post-lumpectomy radiation therapy for treatment of an intracystic papillary carcinoma?

1 Answer available

For early stage breast cancer patients, should lumpectomy + RT be recommended over mastectomy?

Randomized trials in the 1980s demonstrated equivalent survival and disease control outcomes for lumpectomy + RT vs mastectomy, but several recent pop...

1 Answer available

How should bolus be utilized with different types of surgical reconstruction?

Do you have a formalized approach, or is it a case by case decision? Do you use bolus differently for a TRAM, tissue expanders, implants, etc?

1 Answer available

When deciding whether to include an IMN field in a PMRT case, what do you consider a "safe dose" to the heart that you are willing to accept?

Do you prioritize certain dosimetric parameters over others (e.g., considering the Darby report, mean dose to the heart vs. mean LAD dose?)

4 Answers available

How should a contralateral breast cancer be treated when found during a prophylactic mastectomy?

In a patient who recently completed NAC, TM/LND and PMRT for a hormone positive locally advanced breast cancer and is then found to have a contralater...

1 Answer available

For a patient with inflammatory breast cancer after standard initial systemic therapy with only a partial response, do you recommend more systemic therapy, pre-operative radiation, or proceed to modified radical mastectomy?

Assuming the patient is a candidate for either of these treatments?

2 Answers available

Should patients receive PMRT if they just have a positive internal mammary lymph node on imaging and a negative axillary dissection?

If so, what fields should be used?

2 Answers available

Is there a role for adjuvant radiation in phyllodes tumors of the breast?

1 Answer available

Is it feasible to use MV fluoroscopy to monitor the treatment port for left-sided breast cancer with DIBH?

Are there any tips on how to best use this technique?

1 Answer available

What RT fields should be used to treat a triple negative breast cancer with biopsy positive lymph nodes and a pCR to neoadjuvant chemotherapy?

If there is a pCR in the breast and nodes do you treat the breast/chest wall SCV and full axilla? IMNs? Would the type of surgery (lumpect...

2 Answers available

How do you minimize skin toxicity in patients who have a significant amount of breast tissue contacting the couch during prone breast radiotherapy?

If there is a signifcant amount of breast tissue contacting the couch in the prone position, are there strategies that can be used to mitigate po...

1 Answer available

Are there situations where it's appropriate to offer postmastectomy radiation therapy to patients with biopsy-proven M1 disease?

What are the indications for local control of the breast in patients with metastatic breast cancer?

3 Answers available

Do you recommend delayed versus immediate breast reconstruction in patients who will require post-mastectomy radiation therapy?

1 Answer available

Is there data, or even anecdotal reports, of cosmesis or capsular contracture of a previously augmented breast after lumpectomy and hypofractionated whole breast radiation?

1 Answer available

In what situations do you order an Oncotype DX DCIS score for a patient with DCIS?

2 Answers available

Are CHEK2 mutations a contraindication for breast conservation therapy (lumpectomy + RT)?

Should patients be managed similar to BRCA patients and consider bilateral mastectomies as an alternative to BCT?

2 Answers available

When do you consider it too late after lumpectomy to offer adjuvant whole breast radiotherapy?

In a patient not receiving adjuvant chemotherapy who has a delayed consultation due to complications/personal issues, etc, is there a time delay ...

4 Answers available

Is there a way to predict clinically or from CT which patients with left sided breast tumors would benefit more from the prone v. supine position?

Comparison of prone versus supine positioning showed that 85% of patients with left sided breast cancer benefit more from the prone versus supine posi...

1 Answer available

Is there evidence to support partial breast irradiation with daily fractionation?

Since we know that both the "Canadian" fractionation and partial breast irradiation work as treatment for early stage breast cancer in the same patien...

6 Answers available

What is the age cut-off to omit radiation therapy after breast conserving surgery for early stage breast cancer?

The Hughes study looked at women > 70 years of age. In light of the PRIME II results, can women aged 65 - 70 avoid RT or is longer follow up needed...

3 Answers available

What is the appropriate nodal coverage a invasive ductal carcinoma status post lumpectomy with 50% or more of the SLN biopsied (for example, 2 of 4 SLN) showing micrometastases?

Would you change your management based on receptor status (ER/PR+/HER2 neg vs triple neg) or menopausal status (pre vs post menopausal)? Would you tre...

1 Answer available

Is there a role for partial breast RT in DCIS?

Would this be considered acceptable in an older woman with high grade disease?

1 Answer available

In light of the DBCG-IMN study, are you treating internal mammary nodes in women with positive axillary LN who have path CR after neoadjuvant chemotherapy?

1 Answer available

Are there certain clinical scenarios that make you favor a lower whole breast total dose but higher lumpectomy cavity boost?

2 Answers available

Is PMRT routinely recommended for all patients with positive lymph nodes after neoadjuvant chemotherapy?

Can it be avoided in patients with a microscopically positive lymph node?

3 Answers available

Should a lumpectomy cavity boost be given to cN0 patients who receive neo-adjuvant chemotherapy and have a path CR, if planning to complete hypofractionated whole breast radiation?

2 Answers available

When using conventionally fractionated breast RT, does one need to treat the whole breast to 50Gy or is 45Gy, followed by a boost satisfactory?

Dose in many studies were often prescribed to a point rather than a volume and with 3D planning, we may be upping the breast dose. The D2eq dose...

1 Answer available

How does a close DCIS margin factor into surgical and radiation decision making for Stage I invasive ductal carcinoma after breast conserving surgery?

Do you use no tumor on ink for margin even if DCIS is the component close to the margin?

1 Answer available

Would you consider whole breast irradiation in a woman who develops a second primary breast cancer or recurrence after lumpectomy and partial breast balloon brachytherapy and declines mastectomy?

2 Answers available

Does triple negative breast cancer influence your decision to boost an older patient post lumpectomy?

2 Answers available

In patients receiving PMRT do you perform a boost if they have had reconstruction (tissue expanders,…)?

If so, how do you target this boost?

4 Answers available

Do you consider 1.8Gy and 2Gy fraction sizes completely equivalent when performing whole breast radiation therapy?

1 Answer available

Do you administer prophylactic antibiotics during a partial breast balloon brachytherapy treatment course?

2 Answers available

In which patients receiving regional nodal irradiation do you include the internal mammary nodes?

Does the recent Danish Breast Cancer Group IMN study (JCO 11/23/15), showing a survival benefit to IM irradiation in patients with early stage no...

1 Answer available

Is systemic sclerosis an absolute contraindication for breast conserving therapy?

If not, do you have any experience with acceptable late toxicity and cosmesis with whole breast radiation in these patients?

3 Answers available

For locally advanced breast cancer, to what dose do you treat undissected clinically positive level III axilla, SCV or IM nodes?

We sometimes find highly suspicious LNs by CT, PET or MRI in the undissected regional lymphatics, and surgeons may not be willing to perform another o...

2 Answers available

Do you routinely include IMNs for left sided inflammatory breast cancer?

Can the IMNs ever be spared, or would you consider it mandatory for all inflammatory breast cancers?

1 Answer available

Is it safe to treat patients who have thermal burn scars in the field?

E.g. breast? I have found no literature on skin tolerance acutely or chronically.

2 Answers available

Do the results of the GEPAR trials indicate that PMRT based on pre-neoadjuvant chemo risk factors, irrelevant of pCR, should be the standard of care until NSABP B-51 is completed?

The GEPAR trials presented at ASCO 2015 showed increased LRR with the omission of RT in patients who had a pCR after neoadjuvant chemotherapy.

2 Answers available

What factors would make you strongly consider re-irradiation of the chest wall in a patient who has previously undergone whole breast irradiation?

1 Answer available

Given the MA20 results, do you consider CW plus SCV or even regional nodal radiation postmastectomy for pT3N0 with high risk features?

High risk meaning LVI, triple negative, Grade 3, etc?

1 Answer available

For breast cancer patients requiring staging, should one order a CT C/A/P & bone scan or PET scan?

Our Radiation Safety officer reports a higher radiation dose to the patient from the two scans vs the PET.

1 Answer available

Do you consider APBI a reasonable alternative to mastectomy for women with early stage breast cancer and collagen vascular diseases?

Do you put more weight on specific CVDs such as scleroderma as contraindications for any RT?

1 Answer available

For a breast cancer patient treated with a mastectomy who has clear indications for post-mastectomy radiation therapy, what do you consider to be the longest acceptable delay prior to initiating PMRT following surgery?

Is there a time frame for when you may not offer post-mastectomy radiation therapy to a patient who may otherwise benefit from treatment in a typical ...

1 Answer available

In determining the need for regional nodal irradiation following breast cancer surgery, do you consider positive intramammary lymph nodes the same as positive axillary lymph nodes?

Is your decision influenced by factors such as the location of the intramammary nodes and/or the mapping of sentinel nodes to the axilla?

1 Answer available

How do you handle post-op, pre-radiation breast seromas and hematomas?

2 Answers available

Do you have a margin requirement beyond negative for DCIS when considering observation following lumpectomy?

I sometimes receive pathology reports that state the margin is negative but do not quantify DCIS proximity to margin. I typically like a margin of 2-3...

1 Answer available

Do you advise patients to avoid deodorant during breast radiotherapy?

There seem to be good prospective studies (Australian study and Canadian study) which debunk the thought that deodorants/antiperspirants increase skin...

6 Answers available

Is post-mastectomy RT recommended for patients who have a local failure after partial breast irradiation?

If the patient has no pathologic risk factors that would ordinarily necessitate PMRT, do you omit it? Does triple negative subtype affect your decisio...

1 Answer available

Are there situations in which hypofractionated breast RT is acceptable after neoadjuvant chemotherapy and lumpectomy?

2 Answers available

Would you give breast radiotherapy to a patient with a history of bilateral retinoblastoma?

Would the risk of radiation-induced second malignancy outweigh the benefit of locoregional control for a young patient with high grade DCIS?

1 Answer available

How do you manage patients with early stage breast cancer with autoimmune disorders such as rheumatoid arthritis and collagen vascular disorders?

Do you have any concern for increased toxicity when you treat a patient with radiation therapy who has an autoimmune disorder? (hypofractiationation v...

1 Answer available

Would accelerated hypofractionated whole breast irradiation therapy be contraindicated in a patient opting for breast conservation in the setting of breast implants?

1 Answer available

Can the addition of posterior axillary boost (PAB) for breast cancer increase the risk of brachial plexopathy?

With conventional RT, the dose to the brachial plexus should be no more than 50-55Gy max. One exception to this is the addition of PAB in conventional...

1 Answer available

In what situations do you routinely use posterior axillary boost (PAB) for breast cancer radiotherapy?

What is the best evidence available for the benefit of PAB in disease control?

1 Answer available

What is the most accurate method to determine initial tumor size prior to neoadjuvant chemotherapy and mastectomy?

Do you look at pretreatment breast MRI or post surgical assessment of the tumor bed/treatment effect? How would you resolve discrepancies betwee...

1 Answer available

Does the presence of multiple positive intramammary lymph nodes in the setting of negative sentinel lymph nodes cause you to treat regional lymphatics?

Would triple negative disease effect your decision?

1 Answer available

Are there situations where you would use hypofractionated radiotherapy for Stage III breast cancer?

Would it be acceptable to treat a patient with locally advanced breast cancer (ex pT2N2a) s/p lumpectomy with a short course 4 week treatment ins...

2 Answers available

Would you offer PMRT for an axillary-only recurrence after a remote mastectomy and ALND in a patient with early stage breast cancer?

In a patient with a T1 breast cancer who underwent mastectomy and ALND and recurred in the axilla a year later, would you offer RT to the chest wall a...

2 Answers available

Do you make any distinction or have any special consideration when considering a patient for hypofractionation for left versus right breast cancer?

i.e. are there any situations where you may recommend against using hypofractionation for a patient with left sided breast cancer such as dose constra...

1 Answer available

Is there an effective treatment for severe radiation fibrosis of the skin after radiotherapy to the breast or other areas?

I have heard of long term pentoxifylline and Vitamin E daily combination that can prevent and even reverse radiation fibrosis (Delanian et al. JCO 200...

3 Answers available

Do you recommend breast MRI for patients with invasive lobular breast cancer considering breast conservation therapy?

2 Answers available

Is post mastectomy radiation therapy indicated based only on pre chemo MRI and PET CT positive axillary lymphadenopathy, if surgery following neoadjuvant chemo showed CR ?

What if the pre-chemo FNA of the suspicious node is negative?

1 Answer available

Regarding regional nodal irradiation for triple positive breast cancers, how much do you weigh in the availability of effective adjuvant systemic therapies (i.e, hormonal and anti-Her2 therapy) in theory being able to control subclinical nodal disease without the need for RT consolidation?

Borderline cases such as patients that received NAC with a complete response or N1 disease with 1-3 positive nodes make me think frequently about this...

1 Answer available

When do you offer PMRT for clinical T3N0 breast cancer with a pCR after neoadjuvant chemotherapy?

Would extensive residual DCIS (>5cm), hormone receptor negativity, Her2+ status, or age < 40 effect your decision?

2 Answers available

What is the optimal/safest regimen for re-irradiation of a partial chest wall following surgical resection of an isolated chest wall recurrence?

Is there any literature supporting that a gentle fractionation/bid regimen (i.e., 1.5Gy bid x 30 = 45Gy) is safer than a standard fractionation ...

4 Answers available

Do you ever consider treating the axilla in patients with multiple nodes with ITCs?

Does the axilla have to be addressed surgically or with RT, given that the AMAROS trial eligibility criteria were amended to address sentinel lymph no...

2 Answers available

Would you recommend definitive local treatment of locally recurrent breast cancer with a positive contralateral axillary lymph node and no signs of distant metastasis?

Or, as this is presumed metastatic disease, would you recommend systemic treatment and defer RT?

2 Answers available

What is the evidence that we should do anything different in breast cancer patients with 1 to 3 nodes involved versus those with four or more nodes involved?

1 Answer available

Do you use breath hold techniques to minimize heart dose in whole breast radiation?

If so, how do you decide which patients to treat with breath hold vs. free breathing? Do you routinely perform 4D CTs?

2 Answers available

How do you counsel young women who want to become pregnant after breast radiotherapy?

A 40 year old patient receiving post-op RT for breast cancer asked me if there is any risk for her becoming pregnant after completing RT. Eric H...

1 Answer available

What is the treatment volume for primary breast lymphoma?

In a patient with Stage IE DLBCL, is your treatment volume postchemo ISRT or whole breast? Would you consolidate if a lumpectomy was performed prior t...

1 Answer available

Can PMRT be avoided in patients with 1-3 + nodes if they achieve a pCR after neoadjuvant chemotherapy?

1 Answer available

Should N1a breast cancer patients with positive intramammary node metastases but negative axillary sentinel node biopsy receive adjuvant post mastectomy radiation?

For intact breasts, should adjuvant radiation to the lymphatic drainage be added to breast radiation?

1 Answer available

How long should patients wait before undergoing reconstruction following PMRT?

Is it a function of the type of reconstruction contemplated?

2 Answers available

How often do you order follow up mammograms after breast radiotherapy?

The 2013 ASCO guidelines and current NCCN guidelines recommend yearly mammograms but our radiologists are still recommending mammograms every 6 m...

2 Answers available

Do you consider treatment of the supraclavicular region mandatory for breast cancer patients with a chest wall recurrence?

If the patient has negative axillary nodes and no other signs of high risk disease other then a local chest wall failure, do I still need to treat the...

2 Answers available

Is there solid evidence for the proper sequencing of tamoxifen/SERM and breast radiation?

They used to be given concomitantly now they are done sequentially. I can only find conflicting data to justify this trend.

2 Answers available

What is your opinion on IORT for breast with electron brachytherapy?

We have a lot of push from our surgeons to do IORT, do you use the ASTRO APBI criteria? Do you treat off-protocol? Do you use Xoft or Intrabeam?

1 Answer available

Do you order a post-lumpectomy mammogram before starting RT?

If so, do you do this routinely or only in certain circumstances? Is there data to support routine mammogram before breast radiotherapy?

3 Answers available

Should we be more concerned about cardiac toxicity following breast radiotherapy?

In a case-control study by Darby et al in the New England Journal of Medicine, patients treated for breast cancer with radiation were found to have an...

2 Answers available

In the absence of other risk factors, do you treat the regional lymph nodes in triple negative breast cancer?

Or for that matter, offer PMRT on the basis of a patient having triple negative disease?

1 Answer available

Should nodal fields be added to post-mastectomy radiation treatment after neo-adjuvant chemotherapy if there is a CR in the nodes?

1 Answer available

In light of the cosmesis and toxicity outcomes of the RAPID trial, should external beam partial breast irradiation be avoided?

2 Answers available

Can I treat breast nodal volumes with hypofractionation?

With the recently reported START (A and B) trial data from the UK, in which patients were allowed to receive hypfractionated doses to nodal regions, i...

1 Answer available

Should I use Oncotype to determine whether to offer adjuvant radiation to women with DCIS?

I'm not sure how to interpret the results of the study published in JNCI earlier this year.

2 Answers available

How much do you deflate a tissue expander prior to beginning post-mastectomy irradiation?

Do you deflate to a specific volume?

1 Answer available

What do you consider is an acceptable surgical margin for invasive breast cancer?

No tumor at ink? 1-2mm?

1 Answer available

Does current data support use of intraoperative breast radiotherapy?

My institution is considering a major investment/purchase of this technology to complement our existing array of breast radiotherapy options.

2 Answers available

Is irradiation of the supraclavicular and internal mammary lymph nodes now considered the standard of care in women with node positive breast cancer?

In other words, have the results of the MA.20 and EORTC trials changed your practice?

1 Answer available

Which patients with DCIS can be observed following lumpectomy?

Has the recent 12-year ECOG update for surgical excision of DCIS without radiation therapy changed your practice management?

1 Answer available

Papers discussed in this category

J Clin Oncol, 2013 Nov 10

Interim cosmetic and toxicity results from RAPID: a randomized trial of accelerated partial breast irradiation using three-dimensional conformal external beam radiation therapy.

Int J Radiat Oncol Biol Phys, 2013 Mar 1

The effect of dose-volume parameters and interfraction interval on cosmetic outcome and toxicity after 3-dimensional conformal accelerated partial breast irradiation.

Int. J. Radiat. Oncol. Biol. Phys., 2011-05-01

Accelerated partial breast irradiation: 5-year results of the German-Austrian multicenter phase II trial using interstitial multicatheter brachytherapy alone after breast-conserving surgery.

Int. J. Radiat. Oncol. Biol. Phys., 2010-07-15

Reports of unexpected late side effects of accelerated partial breast irradiation--radiobiological considerations.

J Radiother Pract, 2014 Jun

Radiation pneumonitis and pulmonary function with lung dose-volume constraints in breast cancer irradiation.

Radiat Oncol, 2010 Oct 29

Reduction of radiation pneumonitis by V20-constraints in breast cancer.

Radiother Oncol, 2014 Jun

Risk of second primary lung cancer in women after radiotherapy for breast cancer.

Ann Surg, 2010 Sep

Locoregional recurrence after sentinel lymph node dissection with or without axillary dissection in patients with sentinel lymph node metastases: the American College of Surgeons Oncology Group Z0011 randomized trial.

N Engl J Med, 2015 Jul 23

Regional Nodal Irradiation in Early-Stage Breast Cancer.

N Engl J Med, 2015 Jul 23

Internal Mammary and Medial Supraclavicular Irradiation in Breast Cancer.

Int J Radiat Oncol Biol Phys, 2007 Jul 15

Postmastectomy radiation improves the outcome of patients with locally advanced breast cancer who achieve a pathologic complete response to neoadjuvant chemotherapy.

J Clin Oncol, 2012 Nov 10

Predictors of locoregional recurrence after neoadjuvant chemotherapy: results from combined analysis of National Surgical Adjuvant Breast and Bowel Project B-18 and B-27.

J Clin Oncol, 2015 Mar 1

RTOG 9804: a prospective randomized trial for good-risk ductal carcinoma in situ comparing radiotherapy with observation.

J. Clin. Oncol., 2015 Sep 14

Surgical Excision Without Radiation for Ductal Carcinoma in Situ of the Breast: 12-Year Results From the ECOG-ACRIN E5194 Study.

N Engl J Med, 2013 Mar 14

Risk of ischemic heart disease in women after radiotherapy for breast cancer.

Int J Radiat Oncol Biol Phys, 2010 Jul 15

Initial efficacy results of RTOG 0319: three-dimensional conformal radiation therapy (3D-CRT) confined to the region of the lumpectomy cavity for stage I/ II breast carcinoma.

Ann Surg Oncol, 2013 Oct

Treatment efficacy with accelerated partial breast irradiation (APBI): final analysis of the American Society of Breast Surgeons MammoSite(®) breast brachytherapy registry trial.

Lancet, 2014 Feb 15

Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial.

Brachytherapy, 2014 Jan-Feb

RTOG 95-17, a Phase II trial to evaluate brachytherapy as the sole method of radiation therapy for Stage I and II breast carcinoma--year-5 toxicity and cosmesis.

Lancet Oncol., 2013-12-01

Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial.

J Clin Oncol, 2013 Jul 1

Lumpectomy plus tamoxifen with or without irradiation in women age 70 years or older with early breast cancer: long-term follow-up of CALGB 9343.

Int. J. Radiat. Oncol. Biol. Phys., 2006-12-01

Targeted intraoperative radiotherapy (TARGIT) yields very low recurrence rates when given as a boost.

J Natl Cancer Inst, 2013 May 15

A multigene expression assay to predict local recurrence risk for ductal carcinoma in situ of the breast.

Lancet Oncol., 2013-04-01

Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial.

Lancet Oncol., 2008-04-01

The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial.

Lancet, 2008-03-29

The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial.

Lancet Oncol., 2013-10-01

The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials.

Radiology, 2012-08-01

Benefit of semiannual ipsilateral mammographic surveillance following breast conservation therapy.

JAMA, 2011 Feb 9

Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial.

J Clin Oncol, 2014 Aug 18

Radiation Field Design in the ACOSOG Z0011 (Alliance) Trial.

Lancet Oncol., 2014-11-01

Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial.

Lancet, 2014 Jun 21

Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials.

N. Engl. J. Med., 1997-10-02

Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer.

N. Engl. J. Med., 1997-10-02

Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial.

Lancet, 1999-05-15

Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial.

Radiother Oncol, 2007-03-01

Is the benefit of postmastectomy irradiation limited to patients with four or more positive nodes, as recommended in international consensus reports? A subgroup analysis of the DBCG 82 b&c randomized trials.

Int J Radiat Oncol Biol Phys, 2009 Jul 15

Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO).

Int J Radiat Oncol Biol Phys, 1990 Oct

Isolated local-regional recurrence of breast cancer following mastectomy: radiotherapeutic management.

Plast Reconstr Surg, 2011 Jun

A multidisciplinary protocol for planned skin-preserving delayed breast reconstruction for patients with locally advanced breast cancer requiring postmastectomy radiation therapy: 3-year follow-up.

Plast Reconstr Surg, 2012 Sep

Increasing the time to expander-implant exchange after postmastectomy radiation therapy reduces expander-implant failure.

Radiother Oncol, 2001-03-01

The impact of skin washing with water and soap during breast irradiation: a randomized study.

J. Clin. Oncol., 2004-04-15

Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer.

Radiother Oncol, 2014-01-01

Prophylactic use of Mepitel Film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients.

Int J Radiat Oncol Biol Phys, 2015 Oct 1

RTOG Chest Wall Contouring Guidelines for Post-Mastectomy Radiation Therapy: Is It Evidence-Based?

Int J Radiat Oncol Biol Phys, 2012 Sep 10

Impact of Margin Status on Local Recurrence After Mastectomy for Ductal Carcinoma In Situ.

Int J Radiat Oncol Biol Phys, 2011 May 1

Is radiation indicated in patients with ductal carcinoma in situ and close or positive mastectomy margins?

Int J Radiat Oncol Biol Phys, 2011 Nov 1

Patterns and risk factors of locoregional recurrence in T1-T2 node negative breast cancer patients treated with mastectomy: implications for postmastectomy radiotherapy.

J Clin Oncol, 2014 Feb 20

Reducing local therapy in patients responding to preoperative systemic therapy: are we outsmarting ourselves?

J Clin Oncol, 2009 Jan 1

Intervals longer than 20 weeks from breast-conserving surgery to radiation therapy are associated with inferior outcome for women with early-stage breast cancer who are not receiving chemotherapy.

J Clin Oncol, 2003 Feb 1

Does delay in starting treatment affect the outcomes of radiotherapy? A systematic review.

N. Engl. J. Med., 2010-02-11

Long-term results of hypofractionated radiation therapy for breast cancer.

Clin Breast Cancer, 2008 Jun

Feasibility of accelerated whole-breast radiation in the treatment of patients with ductal carcinoma in situ of the breast.

Int J Radiat Oncol Biol Phys, 2013 Oct 8

Hypofractionated Radiation Therapy for Breast Ductal Carcinoma In Situ.

Lancet Oncol., 2012-01-01

Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial.

N. Engl. J. Med., 2015-02-19

Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer.

Ann. Oncol., 2014-05-01

Tumor factors predictive of response to hypofractionated radiotherapy in a randomized trial following breast conserving therapy.

Radiother Oncol, 2012-12-01

Deodorant use and the risk of skin toxicity in patients undergoing radiation therapy for breast cancer: a meta-analysis.

N Engl J Med, 2002 Aug 22

Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation.

J. Clin. Oncol., 2004-01-01

Axillary treatment in conservative management of operable breast cancer: dissection or radiotherapy? Results of a randomized study with 15 years of follow-up.

Int J Radiat Oncol Biol Phys, 2011 Nov 1

Local-regional recurrence with and without radiation therapy after neoadjuvant chemotherapy and mastectomy for clinically staged T3N0 breast cancer.

Int J Radiat Oncol Biol Phys, 2012 Jun 1

Role of postmastectomy radiation after neoadjuvant chemotherapy in stage II-III breast cancer.

J Clin Oncol, 2014 May 10

Margins for breast-conserving surgery with whole-breast irradiation in stage I and II invasive breast cancer: American Society of Clinical Oncology endorsement of the Society of Surgical Oncology/American Society for Radiation Oncology consensus guideline.

Lancet Oncol., 2015-01-01

Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial.

Radiother Oncol, 2009-01-01

Impact of the boost dose of 10 Gy versus 26 Gy in patients with early stage breast cancer after a microscopically incomplete lumpectomy: 10-year results of the randomised EORTC boost trial.

Breast J, 2011 Nov-Dec

ACR appropriateness criteria® locally advanced breast cancer.

Int J Radiat Oncol Biol Phys, 2011 Sep 1

Fractionation for whole breast irradiation: an American Society for Radiation Oncology (ASTRO) evidence-based guideline.

Int J Radiat Oncol Biol Phys, 2004 Dec 1

Biologic comparison of partial breast irradiation protocols.

Br J Radiol, 1988-07-01

The 10-year results of a prospective trial of post-operative radiotherapy delivered in 3 fractions per week versus 2 fractions per week in breast carcinoma.

J. Natl. Cancer Inst., 2005-01-19

Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial.

N. Engl. J. Med.,

Hypofractionated radiotherapy for breast cancer.

Radiother Oncol, 2017 Nov 15

Late normal tissue effects in the arm and shoulder following lymphatic radiotherapy: Results from the UK START (Standardisation of Breast Radiotherapy) trials.

Lancet, 2017-09-09

Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial.

Pract Radiat Oncol, 2018 Mar 08

Radiation therapy for the whole breast: Executive summary of an American Society for Radiation Oncology (ASTRO) evidence-based guideline.

J. Clin. Oncol., 1997-07-01

Irradiation in the setting of collagen vascular disease: acute and late complications.

J Clin Oncol, 2006 Aug 20

Low locoregional recurrence rate among node-negative breast cancer patients with tumors 5 cm or larger treated by mastectomy, with or without adjuvant systemic therapy and without radiotherapy: results from five national surgical adjuvant breast and bowel project randomized clinical trials.

Radiother Oncol, 2011-08-01

Adjuvant chemotherapy and radiotherapy in triple-negative breast carcinoma: a prospective randomized controlled multi-center trial.

J Clin Oncol, 2012 Nov 26

Long-Term Results of RTOG 91-11: A Comparison of Three Nonsurgical Treatment Strategies to Preserve the Larynx in Patients With Locally Advanced Larynx Cancer.

J. Clin. Oncol., 2015-06-20

Identification of a Low-Risk Luminal A Breast Cancer Cohort That May Not Benefit From Breast Radiotherapy.

J Clin Oncol, 2009 Oct 20

Impact of pathological characteristics on local relapse after breast-conserving therapy: a subgroup analysis of the EORTC boost versus no boost trial.

Acta Oncol, 2014-10-01

Relationship between the prognostic and predictive value of the intrinsic subtypes and a validated gene profile predictive of loco-regional control and benefit from post-mastectomy radiotherapy in patients with high-risk breast cancer.

J. Clin. Oncol., 2016-12-20

Postmastectomy Radiotherapy: An American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Focused Guideline Update.

J. Clin. Oncol.,

Postmastectomy radiotherapy: clinical practice guidelines of the American Society of Clinical Oncology.

J. Clin. Oncol., 2006 Apr 17

Study of failure pattern among high-risk breast cancer patients with or without postmastectomy radiotherapy in addition to adjuvant systemic therapy: long-term results from the Danish Breast Cancer Cooperative Group DBCG 82 b and c randomized studies.

J Clin Oncol, 2006 Mar 1

Prospective study of wide excision alone for ductal carcinoma in situ of the breast.

Brachytherapy, 2011 Mar-Apr

The use of adjuvant high-dose-rate breast brachytherapy in patients with collagen vascular disease: a collaborative experience.

Brachytherapy, 2011 Nov-Dec

Partial breast irradiation in a patient with bilateral breast cancers and CREST syndrome.

Lancet Oncol, 2014 Feb

Chemotherapy for isolated locoregional recurrence of breast cancer (CALOR): a randomised trial.

Int J Radiat Oncol Biol Phys, 2006 Oct 1

Low local recurrence rate without postmastectomy radiation in node-negative breast cancer patients with tumors 5 cm and larger.

J Clin Oncol, 2006 May 1

Sequential preoperative or postoperative docetaxel added to preoperative doxorubicin plus cyclophosphamide for operable breast cancer:National Surgical Adjuvant Breast and Bowel Project Protocol B-27.

Lancet, 2014 Jul 12

Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis.

J Clin Oncol, 1997 Jul

Effect of preoperative chemotherapy on local-regional disease in women with operable breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-18.

Int J Radiat Oncol Biol Phys, 2012 Aug 1

Pretreatment staging positron emission tomography/computed tomography in patients with inflammatory breast cancer influences radiation treatment field designs.

Int J Radiat Oncol Biol Phys, 2008 May 1

Multi-institutional experience using the MammoSite radiation therapy system in the treatment of early-stage breast cancer: 2-year results.

J Clin Oncol, 2007 Jun 1

Phase I-II trial of prone accelerated intensity modulated radiation therapy to the breast to optimally spare normal tissue.

Int J Radiat Oncol Biol Phys, 2012 Nov 15

Five-year local control in a phase II study of hypofractionated intensity modulated radiation therapy with an incorporated boost for early stage breast cancer.

J. Clin. Oncol., 2016-02-01

DBCG-IMN: A Population-Based Cohort Study on the Effect of Internal Mammary Node Irradiation in Early Node-Positive Breast Cancer.

J. Clin. Oncol., 2016-02-01

Radiation of the Internal Mammary Nodes: Is There a Benefit?

N. Engl. J. Med.,

Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy.

Int J Radiat Oncol Biol Phys, 2012 Nov 1

Prone accelerated partial breast irradiation after breast-conserving surgery: five-year results of 100 patients.

Eur. J. Cancer, 2015-03-01

Accelerated partial breast irradiation using intensity-modulated radiotherapy versus whole breast irradiation: 5-year survival analysis of a phase 3 randomised controlled trial.

Int. J. Radiat. Oncol. Biol. Phys., 2016-03-01

Patterns of Local-Regional Management Following Neoadjuvant Chemotherapy in Breast Cancer: Results From ACOSOG Z1071 (Alliance).

Lancet Oncol., 2015-03-01

Breast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomised controlled trial.

N. Engl. J. Med., 2004-09-02

Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer.

Eur. J. Cancer, 2013-07-01

Radiotherapy or tamoxifen after conserving surgery for breast cancers of excellent prognosis: British Association of Surgical Oncology (BASO) II trial.

Int. J. Radiat. Oncol. Biol. Phys., 2007-06-01

Lumpectomy plus tamoxifen or anastrozole with or without whole breast irradiation in women with favorable early breast cancer.

Radiat Oncol, 2012 Sep 24

Is there an advantage to delivering breast boost in the lateral decubitus position?

Int J Radiat Oncol Biol Phys, 2012 Mar 1

Prone hypofractionated whole-breast radiotherapy without a boost to the tumor bed: comparable toxicity of IMRT versus a 3D conformal technique.

Int J Radiat Oncol Biol Phys, 2016 Jun 1

Prospective Randomized Trial of Prone Accelerated Intensity Modulated Breast Radiation Therapy With a Daily Versus Weekly Boost to the Tumor Bed.

Breast Cancer Res Treat, 2015 Jul

A population-based validation study of the DCIS Score predicting recurrence risk in individuals treated by breast-conserving surgery alone.

Ann Surg Oncol, 2009 Aug

A prospective, multi-institutional study of adjuvant radiotherapy after resection of malignant phyllodes tumors.

Radiat Med, 1999 May-Jun

Evaluation of small internal mammary lymph node metastases in breast cancer by MRI.

Breast J, 1999 Jan

Mammographically Occult Breast Cancers.

Ann Surg Oncol, 2010 Oct

Impact of breast density on the presenting features of malignancy.

Blood, 2015 May 18

Intracranial hemorrhage in patients with brain metastases treated with therapeutic enoxaparin: a matched cohort study.

Lancet Oncol, 2010 Jan

Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial.

N Engl J Med, 2004 Dec 30

A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.

J Clin Oncol, 2002 Oct 15

Tamoxifen, radiation therapy, or both for prevention of ipsilateral breast tumor recurrence after lumpectomy in women with invasive breast cancers of one centimeter or less.

Eur. J. Cancer, 1993-01-01

The cosmetic outcome in early breast cancer treated with sector resection with or without radiotherapy. Uppsala-Orebro Breast Cancer Study Group.

Eur. J. Cancer, 2010-01-01

Radiation therapy and tamoxifen after breast-conserving surgery: updated results of a 2 x 2 randomised clinical trial in patients with low risk of recurrence.

Semin Radiat Oncol, 2008 Oct

An overview of hypofractionation and introduction to this issue of seminars in radiation oncology.

J Clin Oncol, 2009 Jun 10

Feasibility trial of partial breast irradiation with concurrent dose-dense doxorubicin and cyclophosphamide in early-stage breast cancer.

Int J Radiat Oncol Biol Phys, 2006 Feb 1

Prospective evaluation of concurrent paclitaxel and radiation therapy after adjuvant doxorubicin and cyclophosphamide chemotherapy for Stage II or III breast cancer.

J Clin Oncol, 2003 Mar 15

Improved outcomes from adding sequential Paclitaxel but not from escalating Doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer.

J. Natl. Cancer Inst., 2001-12-05

Risk of pneumonitis in breast cancer patients treated with radiation therapy and combination chemotherapy with paclitaxel.

Int. J. Radiat. Oncol. Biol. Phys., 2000-09-01

Concurrent radiation therapy and paclitaxel or docetaxel chemotherapy in high-risk breast cancer.

Breast Cancer Res Treat, 2010 Dec

Preoperative concurrent paclitaxel-radiation in locally advanced breast cancer: pathologic response correlates with five-year overall survival.

Int J Radiat Oncol Biol Phys, 2012 Aug 1

Int. J. Radiat. Oncol. Biol. Phys., 2011-11-15

Early-stage young breast cancer patients: impact of local treatment on survival.

Breast, 2015-06-01

Overall survival according to type of surgery in young (?40 years) early breast cancer patients: A systematic meta-analysis comparing breast-conserving surgery versus mastectomy.

Int. J. Radiat. Oncol. Biol. Phys., 1990-11-01

The use of a specific hypofractionated radiation therapy regimen versus classical fractionation in the treatment of breast cancer: a randomized study of 230 patients.

Int. J. Radiat. Oncol. Biol. Phys.,

Mometasone furoate cream reduces acute radiation dermatitis in patients receiving breast radiation therapy: results of a randomized trial.

Lancet, 2016-01-16

5-year results of accelerated partial breast irradiation using sole interstitial multicatheter brachytherapy versus whole-breast irradiation with boost after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: a randomised, phase 3, non-inferiority trial.

N. Engl. J. Med., 2013-06-27

Ischemic heart disease after breast cancer radiotherapy.

J. Clin. Oncol., 2017-04-10

Validation and Modification of a Prediction Model for Acute Cardiac Events in Patients With Breast Cancer Treated With Radiotherapy Based on Three-Dimensional Dose Distributions to Cardiac Substructures.

Pract Radiat Oncol, 2015 Nov 9

Breast, chest wall, and nodal irradiation with prone set-up: Results of a hypofractionated trial with a median follow-up of 35 months.

J Natl Cancer Inst, 2006 Dec 20

Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women's Intervention Nutrition Study.

Med Sci Sports Exerc, 2010 Jul

American College of Sports Medicine roundtable on exercise guidelines for cancer survivors.

J Clin Oncol, 2016 Feb 20

American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline.

Curr Breast Cancer Rep, 2016-01-01

Reducing the Risk of Breast Cancer Recurrence: an Evaluation of the Effects and Mechanisms of Diet and Exercise.

Crit Rev Food Sci Nutr, 2018 Apr 19

Meat, eggs, full-fat dairy, and nutritional boogeymen: Does the way in which animals are raised affect health differently in humans?

JAMA,

Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical Trial.

JAMA Oncol,

Prolonged Nightly Fasting and Breast Cancer Prognosis.

JAMA, 2013 Oct 9

Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: the ACOSOG Z1071 (Alliance) clinical trial.

Breast, 2017-02-01

Using ultrasound and palpation for predicting axillary lymph node status following neoadjuvant chemotherapy - Results from the multi-center SENTINA trial.

J. Clin. Oncol., 2015-01-20

Sentinel node biopsy after neoadjuvant chemotherapy in biopsy-proven node-positive breast cancer: the SN FNAC study.

Int J Radiat Oncol Biol Phys, 2008 Feb 1

Multi-institutional review of repeat irradiation of chest wall and breast for recurrent breast cancer.

Breast Cancer Res Treat, 2010 Jun

Local therapy in BRCA1 and BRCA2 mutation carriers with operable breast cancer: comparison of breast conservation and mastectomy.

Int. J. Radiat. Oncol. Biol. Phys., 2017-03-15

Delineation of Internal Mammary Nodal Target Volumes in Breast Cancer Radiation Therapy.

JAMA Oncol, 2016 Mar

Delayed Initiation of Adjuvant Chemotherapy Among Patients With Breast Cancer.

Clin Oncol (R Coll Radiol), 2016-12-01

The Effect of Waiting Times for Postoperative Radiotherapy on Outcomes for Women Receiving Partial Mastectomy for Breast Cancer: a Systematic Review and Meta-Analysis.

N Engl J Med, 2009 May 14

Adjuvant chemotherapy in older women with early-stage breast cancer.

Ann. Oncol., 2009-02-01

Thymidine phosphorylase expression and benefit from capecitabine in patients with advanced breast cancer.

Clin. Cancer Res., 2015 Jun 03

Patients with Slowly Proliferative Early Breast Cancer Have Low Five-Year Recurrence Rates in a Phase III Adjuvant Trial of Capecitabine.

J. Clin. Oncol., 2011 Nov 21

Adjuvant capecitabine, docetaxel, cyclophosphamide, and epirubicin for early breast cancer: final analysis of the randomized FinXX trial.

Int. J. Radiat. Oncol. Biol. Phys., 2001-07-01

The influence of pathologic tumor characteristics on locoregional recurrence rates following mastectomy.

Int J Radiat Oncol Biol Phys, 2005 Jul 15

Locoregional recurrence rates and prognostic factors for failure in node-negative patients treated with mastectomy: implications for postmastectomy radiation.

Int. J. Radiat. Oncol. Biol. Phys., 2016-04-01

Hyperthermia and Radiation Therapy in Locoregional Recurrent Breast Cancers: A Systematic Review and Meta-analysis.

Int. J. Radiat. Oncol. Biol. Phys., 2017-11-15

Concurrent Neoadjuvant Chemotherapy and Radiation Therapy in Locally Advanced Breast Cancer.

Breast Cancer Res Treat, 2009 Mar

Pulsed reduced dose-rate radiotherapy: a novel locoregional retreatment strategy for breast cancer recurrence in the previously irradiated chest wall, axilla, or supraclavicular region.

J. Clin. Oncol., 2011-07-20

Increased risk of locoregional recurrence for women with T1-2N0 triple-negative breast cancer treated with modified radical mastectomy without adjuvant radiation therapy compared with breast-conserving therapy.

Brachytherapy, 2017 Sep - Oct

American Brachytherapy Society consensus report for accelerated partial breast irradiation using interstitial multicatheter brachytherapy.

Pract Radiat Oncol, 2017 Mar - Apr

Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement.

Int J Radiat Oncol Biol Phys, 2012 Nov 22

Evaluation of Current Consensus Statement Recommendations for Accelerated Partial Breast Irradiation: A Pooled Analysis of William Beaumont Hospital and American Society of Breast Surgeon MammoSite(®) Registry Trial Data.

Crit. Rev. Oncol. Hematol., 2009-08-01

Optimal timing for adjuvant radiation therapy in breast cancer: a comprehensive review and perspectives.

Lancet Oncol., 2013-06-01

Sentinel-lymph-node biopsy in patients with breast cancer before and after neoadjuvant chemotherapy (SENTINA): a prospective, multicentre cohort study.

Pract Radiat Oncol, 2014 Mar-Apr

Outcomes and toxicities of stereotactic body radiation therapy for non-spine bone oligometastases.

Int. J. Radiat. Oncol. Biol. Phys., 2018-01-01

Breast Cancer Biology: Clinical Implications for Breast Radiation Therapy.

Int. J. Radiat. Oncol. Biol. Phys., 2017 May 03

A Phase 2 Study of Preoperative Capecitabine and Concomitant Radiation in Women With Advanced Breast Cancer.

J. Clin. Oncol., 2018 Feb 14

Efficacy of Chemotherapy for ER-Negative and ER-Positive Isolated Locoregional Recurrence of Breast Cancer: Final Analysis of the CALOR Trial.

Lancet Oncol.,

Radiotherapy in the setting of breast reconstruction: types, techniques, and timing.

Cancer, 2018 Feb 26

The patient's perspective on breast radiotherapy: Initial fears and expectations versus reality.

Proc Natl Acad Sci U S A, 2015 Aug 3

Countering antivaccination attitudes.

J Natl Cancer Inst, 2018 Jan 1

Use of Alternative Medicine for Cancer and Its Impact on Survival.

Pediatrics, 2014 Mar 03

Effective messages in vaccine promotion: a randomized trial.

Vaccine, 2014 Dec 08

Does correcting myths about the flu vaccine work? An experimental evaluation of the effects of corrective information.

PLoS ONE, 2013 Feb 06

Influence of the presence of tissue expanders on energy deposition for post-mastectomy radiotherapy.

J Clin Oncol, 2006 Sep 1

Long-term cardiac tolerability of trastuzumab in metastatic breast cancer: the M.D. Anderson Cancer Center experience.

Int. J. Radiat. Oncol. Biol. Phys., 2014 May 24

Prone breast intensity modulated radiation therapy: 5-year results.

Breast, 2010 May 18

The impact of the loco-regional treatment in elderly breast cancer patients: hypo-fractionated exclusive radiotherapy, single institution long-term results.

J. Clin. Oncol.,

Regional nodal failure after conservative surgery and radiotherapy for early-stage breast carcinoma.

Int J Radiat Oncol Biol Phys, 2017 Jun 1

Postmastectomy Radiation Therapy Is Associated With Improved Survival in Node-Positive Male Breast Cancer: A Population Analysis.

Cancer, 2003 Apr 15

Angiosarcoma after breast-conserving therapy.

Int J Radiat Oncol Biol Phys, 2002 Mar 1

Angiosarcoma after breast-conserving therapy: experience with hyperfractionated radiotherapy.

J Surg Oncol,

Primary sarcoma of the breast.

Breast Cancer Res. Treat.,

Primary breast sarcoma: a review of 33 cases with immunohistochemistry and prognostic factors.

J. Clin. Oncol.,

Prognostic factors in primary breast sarcomas: a series of patients with long-term follow-up.

Int. J. Radiat. Oncol. Biol. Phys.,

Primary soft tissue sarcomas of the breast: local-regional control with post-operative radiotherapy.

Int. J. Radiat. Oncol. Biol. Phys.,

An analysis of 78 breast sarcoma patients without distant metastases at presentation.

Radiother Oncol,

Role of radiotherapy in sarcoma of the breast--a retrospective review of the M.D. Anderson experience.

Eur. J. Cancer, 2014 Apr 11

Treatment and prognostic factors of radiation-associated angiosarcoma (RAAS) after primary breast cancer: a systematic review.

Radiother Oncol, 2017 Sep 27

Preliminary results of the association of Palbociclib and radiotherapy in metastatic breast cancer patients.

Breast Cancer, 2012 Apr 25

Possible clinical cure of metastatic breast cancer: lessons from our 30-year experience with oligometastatic breast cancer patients and literature review.

Ann. Surg. Oncol., 2018 May 17

Randomized Trial Comparing Resection of Primary Tumor with No Surgery in Stage IV Breast Cancer at Presentation: Protocol MF07-01.

Lancet Oncol., 2015 Sep 09

Locoregional treatment versus no treatment of the primary tumour in metastatic breast cancer: an open-label randomised controlled trial.

Am J Surg, 2004 Aug

Breast-conserving therapy and sentinel lymph node biopsy are feasible in cancer patients with previous implant breast augmentation.

Pract Radiat Oncol, 2017 Sep 08

Subcutaneous implant-based breast reconstruction, a modern challenge in postmastectomy radiation planning.

Int J Radiat Oncol Biol Phys, 2014 Mar 1

The impact of radiation therapy on the risk of lymphedema after treatment for breast cancer: a prospective cohort study.

Breast Cancer Res. Treat.,

Impact of body mass index and weight fluctuation on lymphedema risk in patients treated for breast cancer.

Ann. Surg.,

Immediate Implant Reconstruction Is Associated With a Reduced Risk of Lymphedema Compared to Mastectomy Alone: A Prospective Cohort Study.

Breast Cancer Res. Treat., 2013 Aug 04

Defining a threshold for intervention in breast cancer-related lymphedema: what level of arm volume increase predicts progression?

J. Clin. Oncol., 2015 Dec 07

Impact of Ipsilateral Blood Draws, Injections, Blood Pressure Measurements, and Air Travel on the Risk of Lymphedema for Patients Treated for Breast Cancer.

Lancet Oncol., 2016 Aug 30

Precautions for breast cancer-related lymphoedema: risk from air travel, ipsilateral arm blood pressure measurements, skin puncture, extreme temperatures, and cellulitis.

Clin Breast Cancer, 2018 Feb

Assessing Changes in the Activity Levels of Breast Cancer Patients During Radiation Therapy.

Breast,

The effect of exercise on fatigue and physical functioning in breast cancer patients during and after treatment and at 6 months follow-up: A meta-analysis.

Cancer Res, 2008 Oct 1

Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs.

N. Engl. J. Med.,

The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers.

J. Clin. Oncol.,

Long-Term, Supplemental, One-Carbon Metabolism-Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort.

NPJ Breast Cancer, 2016

Randomized trial of medroxyprogesterone acetate for the prevention of endometrial pathology from adjuvant tamoxifen for breast cancer: SWOG S9630.

J Clin Oncol, 2010 Apr 1

Association between the 21-gene recurrence score assay and risk of locoregional recurrence in node-negative, estrogen receptor-positive breast cancer: results from NSABP B-14 and NSABP B-20.

Cancer, 2010 Jan 15

Radiotherapy for patients with the human immunodeficiency virus: are special precautions necessary?

Cancer,

Breast carcinoma with noninflammatory skin involvement (T4b): time to abandon an historic relic from the TNM classification.

J Clin Oncol, 2005 May 1

Randomized trial of hyperthermia and radiation for superficial tumors.

J Clin Oncol, 2005 Mar 20

Sequencing of chemotherapy and radiation therapy in early-stage breast cancer: updated results of a prospective randomized trial.

Cochrane Database Syst Rev, 2013 Apr 30

Sequencing of chemotherapy and radiotherapy for early breast cancer.

Int. J. Radiat. Oncol. Biol. Phys., 2005 Oct 13

A phase III randomized study on the sequencing of radiotherapy and chemotherapy in the conservative management of early-stage breast cancer.

Clin Breast Cancer, 2014 Jun

Radiation recall reaction with letrozole therapy in breast cancer.

Int J Radiat Oncol Biol Phys, 2017 Jul 1

First Results of a Phase 2 Trial of Once-Weekly Hypofractionated Breast Irradiation (WHBI) for Early-Stage Breast Cancer.

Breast,

Pushing the limits of hypofractionation for adjuvant whole breast radiotherapy.

Brachytherapy, 2018 Jan - Feb

The American Brachytherapy Society consensus statement for accelerated partial-breast irradiation.

Histopathology, 2014 Feb 25

Pleomorphic lobular carcinoma in situ of the breast: clinicopathological review of 47 cases.

Int J Radiat Oncol Biol Phys, 2016 Mar 15

Image Guided Radiation Therapy (IGRT) Practice Patterns and IGRT's Impact on Workflow and Treatment Planning: Results From a National Survey of American Society for Radiation Oncology Members.

Int. J. Radiat. Oncol. Biol. Phys., 2018 Nov 12

Medical Malpractice Analysis in Radiation Oncology: a Decade of Results from a National Comparative Benchmarking System.

Int. J. Radiat. Oncol. Biol. Phys.,

Subareolar breast cancer: long-term results with conservative surgery and radiation therapy.

Med. Oncol., 2012 Jul 28

Surgery of primary tumors in stage IV breast cancer: an updated meta-analysis of published studies with meta-regression.

Int. J. Radiat. Oncol. Biol. Phys., 2018 Apr 19

Hypofractionated Whole-Breast Irradiation in Women Less Than 50 Years Old Treated on 4 Prospective Protocols.

N. Engl. J. Med., 2018 Dec 05

Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer.

Breast J, 2017 Jul 20

Successful case of breast conservation radiotherapy in a patient with type III Ehlers-Danlos syndrome.

Clin Oncol (R Coll Radiol),

Vitiligo and radiotherapy: the Koebner phenomenon demonstrated in patients with vitiligo undergoing radiotherapy for carcinoma of the breast.

JAMA,

Effect of Axillary Dissection vs No Axillary Dissection on 10-Year Overall Survival Among Women With Invasive Breast Cancer and Sentinel Node Metastasis: The ACOSOG Z0011 (Alliance) Randomized Clinical Trial.

Lancet Oncol., 2019 Jan 30

Hypofractionated versus conventional fractionated postmastectomy radiotherapy for patients with high-risk breast cancer: a randomised, non-inferiority, open-label, phase 3 trial.

Int J Radiat Oncol Biol Phys, 2015 Jul 1

Delineation of Supraclavicular Target Volumes in Breast Cancer Radiation Therapy.

Cancer,

Adjuvant postoperative radiotherapy, chemotherapy, and immunotherapy in stage III breast cancer. II. 5-year results and influence of levamisole.

Int. J. Radiat. Oncol. Biol. Phys.,

Evaluation of radiotherapy in high-risk breast cancer patients: report from the Danish Breast Cancer Cooperative Group (DBCG 82) Trial.

J. Clin. Oncol., 2018 Mar 20

Concurrent Veliparib With Chest Wall and Nodal Radiotherapy in Patients With Inflammatory or Locoregionally Recurrent Breast Cancer: The TBCRC 024 Phase I Multicenter Study.

Int J Radiat Oncol Biol Phys, 2006 Sep 1

Do metallic ports in tissue expanders affect postmastectomy radiation delivery?

BMC Cancer, 2017 Dec 11

The prognosis of invasive micropapillary carcinoma compared with invasive ductal carcinoma in the breast: a meta-analysis.

Ann. Surg.,

Relationship Between Margin Width and Recurrence of Ductal Carcinoma In Situ: Analysis of 2996 Women Treated With Breast-conserving Surgery for 30 Years.

J Cancer, 2017 Aug 22

DCIS Margins and Breast Conservation: MD Anderson Cancer Center Multidisciplinary Practice Guidelines and Outcomes.

Int J Radiat Oncol Biol Phys, 2017 Apr 1

Utility of Deep Inspiration Breath Hold for Left-Sided Breast Radiation Therapy in Preventing Early Cardiac Perfusion Defects: A Prospective Study.

Lancet Oncol., 2016 Oct 24

Local consolidative therapy versus maintenance therapy or observation for patients with oligometastatic non-small-cell lung cancer without progression after first-line systemic therapy: a multicentre, randomised, controlled, phase 2 study.

J. Clin. Oncol., 2019 May 08

Local Consolidative Therapy Vs. Maintenance Therapy or Observation for Patients With Oligometastatic Non-Small-Cell Lung Cancer: Long-Term Results of a Multi-Institutional, Phase II, Randomized Study.

Lancet, 2019 Apr 11

Stereotactic ablative radiotherapy versus standard of care palliative treatment in patients with oligometastatic cancers (SABR-COMET): a randomised, phase 2, open-label trial.

Radiother Oncol, 2019 May 17

ESTRO ACROP consensus guideline for target volume delineation in the setting of postmastectomy radiation therapy after implant-based immediate reconstruction for early stage breast cancer.

Cochrane Database Syst Rev, 2017 Nov 06

Tumour bed boost radiotherapy for women after breast-conserving surgery.

Int. J. Radiat. Oncol. Biol. Phys., 2019 Jun 28

Determining the "Organ-at-Risk" for Lymphedema Following Regional Nodal Irradiation in Breast Cancer.

Int. J. Radiat. Oncol. Biol. Phys., 2019 May 11

Development and validation of a nomogram to predict lymphedema following axillary surgery and radiotherapy in women with breast cancer from the NCIC CTG MA.20 randomized trial.

Pract Radiat Oncol, 2016 Nov - Dec

Radiation therapy for right-sided breast cancer in a patient with pectus excavatum: A comparison of treatment techniques.

Int. J. Radiat. Oncol. Biol. Phys., 2019 Jan 04

Three-Fraction Accelerated Partial Breast Irradiation (APBI) Delivered With Brachytherapy Applicators Is Feasible and Safe: First Results From the TRIUMPH-T Trial.

Pract Radiat Oncol, 2018 Jan - Feb

Standardization of nodal radiation therapy through changes to a breast cancer clinical pathway throughout a large, integrated cancer center network.

J Natl Cancer Inst, 2011 Mar 16

Long-term outcomes of invasive ipsilateral breast tumor recurrences after lumpectomy in NSABP B-17 and B-24 randomized clinical trials for DCIS.

Int. J. Radiat. Oncol. Biol. Phys., 2019 Aug 02

The implications of genetic testing on radiotherapy decisions: a guide for radiation oncologists.

Radiation Oncology

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