Inflammatory eye disorders   

The patient has no extraocular features of a spondyloarthropathy and is on methotrexate. No active eye disease for past 1 year.

Patient is asymptomatic. Labs showed +P-ANCA 1:160. Negative MPO and PR3.

Other manifestations improved (renal function has stabilized, fatigue, arthritis, and LCV have resolved). Ophthalmologist has controlled the uveitis u...

Patient with history of toxoplasma chorioretinitis, currently on oral and topical prednisone. 

Patient has failed methotrexate and adalimumab. 

Is the approach different from uveitis immunosuppression?

What immunosuppression and dosing do you typically use?

Without a discrete mass to biopsy, is there any utility of any blind biopsies to rule out IgG4 related disease, infectious or neoplastic process?

Are IL-17 or IL-23 inhibitors helpful?

Patient was previously well controlled on methotrexate, which was discontinued during cancer treatment.