Dermatology
Clinical insights on skin conditions, dermatologic procedures, and treatment approaches from practicing dermatologists.
Recent Discussions
What treatment options are there for uremic pruritus in an elderly patient with risk of sundowning?
Uremic pruritus is increasingly recognized as a multifactorial condition involving peripheral neuropathy and immune dysregulation, particularly upregulation of type 2 cytokine pathways. Dysregulated opioid signaling further contributes to itch amplification. Accordingly, κ-opioid receptor agonists, ...
What is your approach for workup and management of prurigo nodularis?
For work up of prurigo nodularis, I generally order a CBC/diff, CMP, and TSH to assess for underlying causes of pruritus.For management, I emphasize the importance of avoiding manipulation and suggest covering lesions with band-aids to minimize scratching. I start with topical and intralesional ster...
How do you counsel patients with chronic urticaria on the role of stress management strategies in their treatment plan?
There are certain situations or times of the year when increased aeroallergen exposure is expected. It follows that increased vigilance is a management technique for those who suffer with sensitivity to these aeroallergen-induced symptoms in the areas of environmental control, pharmacotherapy, and, ...
Is there an age cut off below you would not treat a keloid with radiation post surgical excision?
While radiotherapy is considered an extremely useful modality in the treatment of recurrent keloids in the adult population, most would contend that the risks do not justify the application of adjuvant radiotherapy in the pediatric population (PMID: 10703484) for a benign condition when other modali...
How would you manage a patient with FFA that is refractory to intralesional steroids, dutasteride, hydroxychloroquine, systemic retinoids and methotrexate?
Oral minoxidil (≤5 mg daily) serves as a reasonable adjunctive therapy for refractory FFA, primarily targeting hair regrowth in non-scarred areas rather than reversing follicular destruction, though evidence remains limited to case series and retrospective studies. Low-dose oral minoxidil has demons...
How is your approach to a patient referred for radiotherapy for keloids with a history of Beals syndrome?
Although of theoretical concern, I am not aware of any contraindication to RT (treatment philosophy similar to Ehlers-Danlos syndrome).
What topical therapies have you found most effective for managing scarring alopecias?
I use a lot of clobetasol shampoo 1-2 times weekly, which is easier and tends to cause less atrophy. Overall, any of the steroid-sparing agents can be helpful: tacrolimus ointment (or compounded as a solution), roflumilast foam, or topical JAK inhibitors. For maintenance.
What is your approach to a patient with undetectable MMR titers checked prior to or during immunosuppression and a history of MMR vaccination in childhood?
MMR titers are good correlates of protection. If any titer is undetectable it could be one of these situations: Primary failure. The components of the MMR have different efficacy. Two doses of appropriately given MMR will have 96+% against measles, but only 88% for mumps. Thus 1 in 10 appropriately...
What is your preferred treatment for actinic cheilitis?
PDT is effective as well as an ablative laser for long-term control. Efudex or imiquimod for multiple weeks is good for localized or milder disease. Consider getting a biopsy if you’re concerned for invasive SCC. Encourage them to use sunscreen too.
What is the appropriate pediatric dose of litfulo for a preadolescent with refractory alopecia areata?
Given that Litfulo is not yet approved for preadolescents and data from clinical trials in this age group are not yet available, it's hard to know the optimal dosing. With that said, typically I would treat a preadolescent with refractory alopecia areata off-label with Litfulo 50 mg (i.e., the same ...