Dermatology
Clinical insights on skin conditions, dermatologic procedures, and treatment approaches from practicing dermatologists.
Recent Discussions
Are there any contraindications to starting a patient on Dupixent for prurigo nodularis if the patient is already on Xolair for asthma?
No, and in fact, I have this combination in several patients.
What therapies have you found most helpful for recalcitrant non-infectious cases of folliculitis?
In my experience, noninfectious folliculitis can be complicated by superficial infections with skin organisms, herpes, or fungi so treatment will include a topical anti-microbial. The folliculitis can be triggered by fragrances in laundry products, irritation by coarse fabrics or occlusion. The prim...
What initial workup do you perform when there is a concern for porphyria?
This is a terrific question. But a broad question. Porphyria refers to a defect in heme biosynthesis leading to the accumulation of porphyrins and porphyrin precursors. We should remember that there are three general categories of porphyria based on clinical manifestations: acute hepatic porphyria (...
What treatments have you found most effective for cholestatic pruritus?
My experience is mainly in Sjogren's or Sjogren's with PBC, ursodiol has been effective. Occasionally, I have used hydroxyzine or H1+H2 blockers. In Sjogren's where the skin biopsy has shown significant lymphocytic infiltration, mycophenolate or a calcineurin inhibitor trial has lead to the resoluti...
What recommendations do you have for treatment-resistant Darier's Disease?
Low dose naltrexone, start in 1 mg and slowly increase to 5 mg pod.
How do you approach treating disseminated granuloma annulare?
I have not found disseminated GA associated with diabetes in my clinical experience even though it has been reported in the literature. Similarly, disseminated GA has been reported with SLE in the literature and I have seen that once in my experience. I would only check for diabetes or SLE if there ...
What is your approach to tapering treatments for patients with bullous pemphigoid?
Oral steroids are generally for acute management and can be tapered as other drugs like doxycycline kick in...typically over a month. Doxy controls most patients pretty well and is safe for long-term Rx. I generally try to taper doxy after a few months without symptoms. Dupilumab is also useful when...
Do patient co-morbidities impact when you prescribe oral jak inhibitors?
Great and pertinent question in our field. Autoimmunity doesn’t make me less likely to prescribe, actually more likely as there is plenty of case report and case series data on JAKi being used in a variety of autoimmune conditions. Certainly, dyslipidemia (think MACE), VTE risk, and malignancy risk ...
What is your approach to managing the initial acne purge while on isotretinoin?
Just start at a lower dose. Add prednisone if really needed. And please don't call it a purge.
Would you recommend continuing Accutane in a teenage female who has experienced a drop in calcium to 8.8 and reductions in albumin and protein levels one month into therapy?
I am curious to know why these labs were checked? And isn't 8.8 a relatively normal calcium level?