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Geriatric Medicine

Geriatric Medicine

Physician insights on aging-related care, polypharmacy management, cognitive decline, and geriatric syndromes.

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Given the "LDL Paradox", in which RA patients with the highest levels of inflammation can have ultra-low levels of LDL (<70), how do you approach initiation of statin therapy in these patients?

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1 Answers

Mednet Member
Mednet Member
Rheumatology · Mayo Clinic

Evaluate lipids at the time of remission/low disease activity and if elevated and the patient is a good candidate for statin therapy, initiate a statin using criteria for the general population.

Do you still plan to offer tofacitinib to RA patients over 65 if they have one or more additional CV risk factors?

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2 Answers

Mednet Member
Mednet Member
Rheumatology · Mayo

I would consider offering tofacitinib (or another JAK inhibitor) to patients over 65 with an additional CV risk factor, but only as a last resort after all other options have been exhausted.

Do you recommend performing cognitive testing in the clinic to determine the blood pressure target in patients 80 years or older?

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1 Answers

Mednet Member
Mednet Member
Nephrology · UAB Medicine

SPRINT-MIND helps to answer this question. The total number of individuals developing dementia (the primary outcome in SPRINT-MIND) was fewer then expected after a median intervention period of only 3.3 years. This made SPRINT-MIND underpowered to detect the effects of intensive BP reduction on deve...