Gynecologic Oncology
Clinical discussions on gynecologic malignancies, surgical approaches, and multimodal treatment strategies.
Recent Discussions
What would you recommend in the adjuvant settings for an elderly patient status post hysterectomy without nodal staging and was found with FIGO 1A, G3 endometrial cancer, with no LVSI and no myometrial involvement, without nodal staging?
Imaging for staging. Brachytherapy alone as adjuvant treatment.
How would you manage bulky cervical adenocarcinoma that incompletely responded to primary chemoradiation?
At the time of surgery, should be evaluated to see whether a radical hysterectomy is visible because of residual disease in parametria and the patient should be prepared for an anterior exenteration if needed.
What is your preferred first line systemic treatment for recurrent, metastatic, low grade, ER/PR+ pMMR endometrioid endometrial carcinoma?
Given the data presented at the most recent SGO Annual Meeting on Women's Cancer, published simultaneously in the New England Journal of Medicine, and recently endorsed by the National Comprehensive Cancer Network (NCCN), the standard of care for recurrent endometrial cancer, regardless of MMR statu...
Do you recommend adjuvant pelvic RT for Stage 1 cervical adenocarcinoma?
At M.D. Anderson we do treat histology as a independent high risk factor - but only moderately to poorly differentiated adenocarcinomas. Grade 1 adenocarcinomas are considered low risk and that histology is not considered as an independent risk factor. So if the case is borderline and the patient ha...
What is the optimal management of a pelvic sidewall recurrence of endometrial cancer in a patient who has not previously received radiation?
A significant percentage of women with a pelvic sidewall recurrence can be salvaged with definitive chemoradiation. We would typically use IMRT, treating a CTV encompassing the pelvic nodes to 45-50 Gy and using an initial integrated boost to treat the gross disease to 50-55. A sequential boost to b...
How do you plan urgent radiation therapy for vaginal bleeding caused by locally advanced cervical cancer?
Agree with @Dr. First Last, we do the same and start at 1.8. Vaginal packing (you can treat with the packing in), transfuse if needed given bleeding. 4-field to start and can turn around a box within a couple hours, and then switch to IMRT as soon as approved. We also try to start the chemo quickly....
When do you offer observation for resected stage II endometrial cancer?
Fortunately, this is an uncommon situation. Even with stage II disease, there is no clear advantage to radical hysterectomy, and it subjects the patient to higher surgical morbidity, especially genitourinary. To my knowledge, data is sparse in terms of when it is appropriate to withhold any adjuvant...
Do you offer pelvic radiation for endometrial cancer with ITCs in the node(s) and no other high or intermediate risk factors?
This is an uncertain area with limited outcome data. Ultrastaging with SNLN is picking up more ITC of which the clinical significance is unclear and may result in overtreatment. The data suggests ITCs have much better outcomes then micro or macromets but possible inferior outcome to node negative di...
For stage IB1 cervical cancer s/p surgery with only 1 Sedlis criteria, should adjuvant pelvic EBRT or vaginal cuff brachytherapy be recommended in the presence of other adverse pathologic features, such as high tumor grade or very close but negative margins?
For patients with close margin would offer EBRT plus brachyhttps://www.ncbi.nlm.nih.gov/pubmed/16750323
How do you treat a Stage I endometrial squamous cell carcinoma?
We have generally managed with same principal as endometriod histology