Nephrology
Clinical discussions on kidney disease management, dialysis, transplantation, and electrolyte disorders.
Recent Discussions
Would you pursue temporary dialysis catheter placement followed by hemodialysis in a hospitalized patient with ESKD who is not able to undergo urgent fistula repair for a non-functioning fistula and receives gadolinium for a MRI study?
There is no role for hemodialysis following the GAD preparations we use these days.
Do you recommend transitioning elderly patients from thiazide diuretics to alternative agents when managing hypertension given the increased concern for hyponatremia in this patient population?
In short, no.If hyponatremia from a thiazide occurs, which is rare (~2% among individuals in the intensive treatment arm of SPRINT), it is more likely to be in the first month after thiazide initiation. Hyponatremia occurring in an individual with chronic thiazide use very likely represents the pres...
Do you prefer allopurinol or febuxostat for patients with chronic kidney disease who are receiving treatment for asymptomatic hyperuricemia?
Allopurinol. For my Asian and sometimes African American patients, I consider HLA testing to make sure they are not at risk for allopurinol hypersensitivity. In which case, I will prescribe febuxostat. Most often, I find the insurance will not even cover febuxostat unless I have tried allopurinol fi...
Under what circumstances would you consider doing a furosemide stress test in the workup of AKI?
Furosemide stress test may be performed early in the course of Stage 1 or 2 AKI to evaluate the likelihood of progression to Stage 3 AKI or the need for renal replacement therapy. A urine output of <200 ml over 2 hours after furosemide administration is predictive of progression to Stage 3 AKI and t...
Do you use a profile with high ultrafiltration rates interrupted by UF pauses to manage ESKD patients prone to intradialytic hypotension?
After exhausting lowering the dialysis bath temperature, extending the time of dialysis (including extra treatments), pure ultrafiltration treatment, and I have tried the UF profile options with varying success.
Would you refer an ESKD patient with an identified living donor for AV access placement if kidney transplantation is anticipated in 4 months?
Good question. I would not because it seems like it would only be a few months that the patient would be able to use the fistula, and I would spare them the surgery. One can make an argument, though, to place one as it may be needed if the transplant fails also. If there is a way one can move up the...
How would you manage an ESKD patient who complains of severe fatigue after hemodialysis, but does not experience intradialytic or post-dialysis hypotension and has not responded to dry weight adjustments?
Difficult but unfortunately not uncommon situation. My theory is that more frequent dialysis would be beneficial to avoid dramatic electrolyte and fluid shifts that occur with intermittent hemodialysis. Would see if peritoneal dialysis or home hemodialysis would be an option. If not, maybe 4 days pe...
Would you refer a patient for kidney only or kidney and liver transplantation if they develop advanced chronic kidney disease secondary to primary hyperoxaluria type 2?
Now that the data suggesting a benefit for nedosiran for PH2 is very disappointing, I think we have to say simultaneous liver and kidney. I have this one experience. My PH2 patient had kidney only because I was thinking that nedosiran would be effective. Ultimately, the kidney failed after about 5 y...
How do you approach vitamin D supplementation in patients with chronic kidney disease, given the findings that vitamin D2 supplementation may lead to decreased conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3?
In early 2000, there was a publication suggesting that ingesting vitamin D2 increases the destruction of vitamin D3 and therefore could increase the risk for vitamin D deficiency. Although I had never seen this happen in my clinic, we decided to conduct a study to evaluate what the effect of vitamin...
Do you prefer automated peritoneal dialysis during the day or night for a hospitalized patient with ESKD on PD?
I am very fortunate to have my home dialysis unit based in the hospital. Thus, our nurses are here and can set up/ take down the machine every day. We perform APD overnight, generally starting at around 5- 6 PM, before the last nurse leaves for the day, and concluding by 3- 4 AM, with the patient th...