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When transitioning a patient with recurrent calcium based nephrolithiasis from one thiazide diuretic to another, do you typically recommend a washout period?

2 Answers
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Nephrology · Mayo Clinic
Answered on

Yes. But since the half-lives of thiazide diuretics differ dramatically, from 1.5 to 2 hours for chlorothiazide to 40 to 60 hours for chlorthalidone, the washout period should be tailored to the specific drugs in question. Checking an electrolyte panel during the transition seems very appropriate to...

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Mednet Member
Mednet MemberInvited Expert
Nephrology · U Chicago
Answered on

I generally do not recommend a washout period. I do not like using hydrochlorothiazide (HCTZ) as it has a short half-life, and I frequently use either chlorthalidone or indapamide.

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