When transitioning a patient with recurrent calcium based nephrolithiasis from one thiazide diuretic to another, do you typically recommend a washout period?
2 Answers
Mednet Member
Nephrology · Mayo Clinic
Yes. But since the half-lives of thiazide diuretics differ dramatically, from 1.5 to 2 hours for chlorothiazide to 40 to 60 hours for chlorthalidone, the washout period should be tailored to the specific drugs in question. Checking an electrolyte panel during the transition seems very appropriate to...