Neurology
Expert perspectives on neurological conditions, stroke management, movement disorders, and neuromuscular disease.
Recent Discussions
When do you consider testing autoimmune antibodies for axonal polyneuropathies without clear etiology?
Dr. @Dr. First Last gave an excellent summary of the clinical red flags that should trigger antibody testing in polyneuropathies. I would like to highlight that not all antibodies are pathogenic or cause the same phenotypes/clinical syndromes, therefore, I would like to break it down by antibody gro...
How do you manage levodopa in a patient with Parkinson's and RLS with augmentation?
Levodopa is known to cause augmentation or worsening of restless leg syndrome (RLS) symptoms (Högl et al., PMID 19756826). There are varying reports of RLS correlation with Parkinson disease (PD) with most studies noting an association (Ondo et al., PMID 11890847; Peralta et al., PMID 19691124; Calz...
What is your approach to evaluating Tardive Dyskinesia in nonverbal patients?
Nonverbal patients can still be affected by TD, so if there is a significant functional impact, treatment can still be offered. If a patient is completely unable to communicate, it is difficult to assess for side effects or symptomatic improvement, so the risk-to-benefit analysis would be largely un...
How do you counsel patients with blepharospasm regarding driving?
I do not have a specific protocol for driving with blepharospasm, so I would advise assessing each case individually. Occupational therapy can perform standardized driving assessments for safety if there is a concern.
Would you consider adding gabapentin off label for use in the treatment of glioblastoma at this time?
As an author on the paper, let me emphasize the findings and speculate on the implications. Recently, a number of laboratories have unraveled stunning preclinical and mechanistic findings demonstrating the ability of a subset of malignant glioma cells to usurp neuronal circuitry to promote tumor gro...
How do you counsel glioblastoma multiforme patients on which types of clinical trials to pursue?
This is a great question! In general, I think that a clinical trial gives someone access to promising therapies (and of course glioblastoma is an aggressive tumor for which we have no cure), but enrolling in one may not feel like the right decision for all patients (for a variety of reasons). I thin...
What is your approach to seronegative presumed pediatric autoimmune encephalitis?
My approach is to prove that the patient has that condition through objective testing (labs, imaging, tissue sampling) instead of having a "presumed" diagnosis as I do not treat patients based on presumptions...
How do you treat rotational vertebral artery syndrome?
I usually take a multidisciplinary approach to treating these patients. I start the patient on an antithrombotic [at least antiplatelet and if any thrombus due to stasis (or significantly slow flow in those who have had a stroke due to thromboembolism from the area of stasis specifically) then antic...
In what circumstances would you consider use of IDH inhibitors in high-grade astrocytomas?
Please forgive me for the length and directness of my response, but I believe it is important to first go over the INDIGO trial and explain why, in my opinion, it was a highly questionable study, with multiple significant methodological flaws and dubious evidence of Vorasidenib's efficacy.INDIGO tri...
When do you consider ultrahigh-dose methylcobalamin injections for ALS?
I have noted that several ALS experts are offering this option nowadays to patients. I will analyze herein why I am NOT in favor of this approach, and, if I would offer methylcobalamin to any of my ALS patients, I would prefer to offer the oral form:1) The reason it is offered is a positive randomiz...