Neurology
Expert perspectives on neurological conditions, stroke management, movement disorders, and neuromuscular disease.
Recent Discussions
How do you balance short-term efficacy against increased low-grade toxicity and quality-of-life considerations for higher single-fraction regimens in recurrent glioma patients?
When considering radiation options for recurrent glioma, in my mind, one size does not fit all. I consider several aspects of the specific patient’s clinical situation: Patient’s prior treatments: time interval, volume, location, and anatomic site, response to prior treatment, response duration from...
How do you counsel patients and doctors on antibiotic avoidance in myasthenia gravis?
I generally recommend avoiding aminoglycosides and most macrolides in MG. The rationale is that there are alternative effective antibiotics for most of the infections covered by the above categories. With fluoroquinolones, however, it's not that simple, because there are some infections that are uni...
Do you generally switch aspirin to another antiplatelet agent if a patient has a non-embolic ischemic stroke and isn't a candidate for DAPT?
I do tend to switch, mainly to impress the patient that I am trying hard to prevent another stroke, and not because there is clear evidence of one antiplatelet over another. Clopidogrel or ticagrelor would be candidates, or I might add cilostazol to aspirin, as this combination has little bleeding r...
To what extent do you incorporate electrodiagnostic testing and ultrasonography in your clinical practice for evaluating suspected cases of meralgia paresthetica?
In my opinion, meralgia paresthetica is one of the easiest diagnoses of focal entrapment neuropathy that a neurologist (or even GP) can make based on clinical exam alone. I don't know any other disorder that presents with isolated sensory symptoms and signs of sensory loss limited to the lateral thi...
How would you approach the consideration of a levodopa trial in an older adult with a history of schizophrenia, stable on antipsychotic medication, who has changes consistent with drug-induced Parkinsonism vs Parkinson's disease?
The first step is to establish if it is degenerative Parkinsonism, such as Parkinson's disease (presynaptic dopaminergic loss) or drug-induced Parkinsonism DIP (due to postsynaptic dopaminergic blockade). I will order a DaT scan to differentiate between the two. If the DaT scan is abnormal, I will s...
Would you consider using IVIG for POTS in the absence of any clear autoimmune condition or abnormal antibodies?
I completely agree with the answer above. It would be a pretty rare consideration, overall. Recent placebo-controlled and blinded studies examining the efficacy of IVIG for idiopathic or antibody-associated (FGFR, TSHDS) small fiber neuropathy found no benefit of the treatment in terms of small fibe...
How do you factor in a negative tilt table test in the workup for patients with suspected autonomic dysfunction?
Autonomic dysfunction encompasses a wide range of symptoms and conditions, making it more of a descriptor than a specific diagnosis. It's akin to diagnosing "lung dysfunction" or a "blood disorder". The next question should be "Which one?" or "Tell me more.". When assessing autonomic symptoms, it's ...
What is the significance of elevated fractionated catecholamines in POTS?
Dear Dr. @Dr. First Last,I don't think we understand the pathophysiology of POTS well enough to comprehensively answer this question.There are a number of technical issues that come into play when drawing serum catecholamines.First of all, many things can elevate catecholamines temporarily: exercise...
Would you consider giving thrombolytic therapy for patients with acute vision loss concerning for CRAO based on history and within the window before any ophthalmological assessment and confirmation?
We have utilized a prior study to give tPA or tenecteplase within 4.5 hours of onset for CRAO. I would not do so, however, without an ophthalmology evaluation to confirm the likely diagnosis and to exclude an alternative diagnosis such as a retinal detachment.
When do you attribute tremors to lamotrigine?
Not a side effect of LTG, but tremors are common and patients love to attribute everything to medications.