How does comorbid epilepsy influence your decision on antipsychotic medications?

In general, epilepsy is not a contraindication to the use of antipsychotic medications if they are needed despite the known risk of lowering the seizure threshold. In general, the risk of seizures for most antipsychotics is low, though some antipsychotics, such as clozapine, olanzapine, and quetiapi...

Carefully, to say the least.

A number of meds lower the seizure threshold.

It is important to ensure that anti-epileptics are at a therapeutic level.

Also have an EKG to see the rhythm, QTC, and conduction defects.