Primary Care

Male and Female Reproductive Disorders

Questions discussed in this category

How would you work-up an older male patient with elevated testosterone-level-for-age?

Example: Age 50s-60s with free & total testosterone levels above 120 pg/ml & 800 ng/dl respectively.

Is there any evidence that spironolactone or finasteride therapy increase blood levels of testosterone?

In a young male patient with hypogonadotropic hypogonadism and fertility goals, would starting testosterone replacement therapy affect fertility chances?

2 Answers available

Is there any benefit of using aspirin to mitigate VTE risk in testosterone-induced polycythemia?

2 Answers available

How should we approach the management of PCOS in transgender men seeking virilization?

1 Answer available

Do oral contraceptives lower bone mineral density in women with hypothalamic amenorrhea by lowering IGF-1?

1 Answer available

When would you treat mild anemia from low testosterone in an older male?

Would you consider testosterone therapy if he is otherwise asymptomatic?

2 Answers available

When do you recommend the use of oral testosterone replacement over injectable testosterone?

Ahmad et al., PMID 36106278

1 Answer available

What is the optimal anti androgen dose of spironolactone when treating female hirsutism?

1 Answer available

How long does it take the hypothalamic-pituitary-gonadal axis to recover from secondary amenorrhea in the setting early onset and chronic use of oral combined contraceptive pills?

1 Answer available

Do you recommend the use of GLP 1 R agonist therapy for obese women with PCOS who are actively trying to conceive?

Dao et al., PMID 38663923

2 Answers available

Is a history of provoked DVT a contraindication to starting testosterone replacement therapy in a middle aged man with symptomatic hypogonadism who is on anti-coagulation?

1 Answer available

Is active smoking a contraindication to starting menopausal hormone therapy (HRT) in a post-menopausal woman with severe vasomotor symptoms and no other cardiovascular risk factors?

1 Answer available

Do you recommend using anastrazole in men developing gynecomastia while on testosterone replacement treatment for hypogonadism depending on pre-treatment estradiol level?

1 Answer available

Should testosterone replacement be stopped in elderly men who suffered acute stroke even when testosterone levels have been stably in the low-to-mid normal range?

1 Answer available

Would you recommend prescribing testosterone replacement therapy to reduce osteoporosis fracture rates in men with hypogonadism?

1 Answer available

Papers discussed in this category

The New England journal of medicine, 2023 Jun 16

Cardiovascular Safety of Testosterone-Replacement Therapy.

The New England journal of medicine, 2013 Sep 12

Gonadal steroids and body composition, strength, and sexual function in men.

The Journal of clinical endocrinology and metabolism, 2023 Sep 18

Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome.

European journal of endocrinology, 2018 Apr 27

Liraglutide increases IVF pregnancy rates in obese PCOS women with poor response to first-line reproductive treatments: a pilot randomized study.

BMJ open, 2024 Apr 24

Use of GLP1 receptor agonists in early pregnancy and reproductive safety: a multicentre, observational, prospective cohort study based on the databases of six Teratology Information Services.

Clinical endocrinology, 1978 Nov

Endocrine effects of spironolactone in man.

The Journal of steroid biochemistry and molecular biology, 2013 Mar 06

Effect of finasteride on serum levels of androstenedione, testosterone and their 5α-reduced metabolites in men at risk for prostate cancer.

The Journal of clinical endocrinology and metabolism, 2007-05

The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men.

The Journal of clinical endocrinology and metabolism, 1975 Oct

Effect of spironolactone on sex hormones in man.

Clinical endocrinology, 1978 Dec

Increased serum oestrone and oestradiol following spironolactone administration in hypertensive men.

The Journal of clinical endocrinology and metabolism, 2018 May 01

Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline.

The Journal of urology, 2022 Jan 20

Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venous Thromboembolism in the First Year of Therapy.

Haematologica, 2009 Oct 14

Hematocrit and risk of venous thromboembolism in a general population. The Tromso study.

American journal of hematology, 2023 Jul 20

Sodium-glucose co-transporter-2 inhibitor therapy and unmasking of JAK2-mutated myeloproliferative neoplasm: A Mayo Clinic series of nine consecutive cases.

PloS one, 2017 Sep 08

Clomiphene citrate effect in obese men with low serum testosterone treated with metformin due to dysmetabolic disorders: A randomized, double-blind, placebo-controlled study.

Primary Care

Male and Female Reproductive Disorders

Questions discussed in this category

Papers discussed in this category

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