Radiation Oncology
Expert insights on radiation treatment planning, techniques, toxicity management, and multimodal cancer care.
Recent Discussions
How would you suggest to radiate a Kaposi's sarcoma?
Although you already have some excellent answers, I would like to add a note about Non HIV KS of the feet and hands (so called endemic variety) as sometimes seen in older men of Mediterranean origin. The challenge in this situation is to offer a therapy that produces durable control w/o serious toxi...
Do you recommend concurrent or sequential radiation and chemotherapy for margin-positive, node negative NSCLC?
We recently looked at outcomes with sequencing of PORT and chemotherapy in patients with pN2 disease and R0, or pN2 R1/R2 resection in the NCDB (J Clin Oncol 2017 Dec 13:JCO2017744771). This group is not exactly the pN0 patient population that is the focus of this question, however, in the R0 pN2 gr...
What is your strategy for treating headaches in patients with history of brain tumor?
Not all headaches in patients with brain tumors arise in the context of elevated ICP, but there are other mechanisms (dural irritation, traction on blood vessels, post-craniotomy pain, for example) by which they can be related. If the headache otherwise seems migrainous, I would treat it as migraine...
Have the final results of the OPERA trial changed the way you approach organ preservation in rectal cancer?
Great question. The OPERA results were certainly promising with 3-year organ preservation rates at 97% for tumors less than 3 centimeters. Patients neither received TME nor doublet chemotherapy (no oxaliplatin). Importantly, it was also the first randomized trial showing a higher dose of radiotherap...
Would you consider post operative boost radiation for positive margin in a patient with rectal cancer who underwent short course RT (25 Gy in 5 fractions) prior to TME?
I realize this is a controversial question, but no I would not. There is no way to know if the cells present at the margin are clonogenicly viable or not. If you look at the results of the Dutch TME trial and the MRC CO 7 trials, patients with positive margin after short course radiation had around ...
When would you consider omitting breast radiation in a <65 yo woman who is s/p BCS?
Off trial, I do not consistently recommend omission of radiation for patients younger than 65. There are studies underway looking at omission in lower risk (ex. luminal A) in patients younger than 65 and studies looking at older randomized trials suggest such a low risk cohort may exist.I do conside...
Should all pediatric CNS cases be referred to a proton center?
I hope there will be a substantial amount of debate on this question, and so I have invited several pediatric radiation oncologists treating patients at institutions where protons are and are not utilized. The weight of the building data on this topic in the literature is mounting such that more and...
Is there any advantage to proton beam therapy in a locally recurrent anal carcinoma, which has already been treated with concurrent chemo RT as well as APR for relapse?
Even with a local recurrence, patients’ life expectancy can be relatively long, which often introduces the question of repeating radiation treatment. Although this option must be balanced with the potential toxicities and consequences of re-treatment, the possible morbidity from tumor progression is...
Do you recommend adjuvant RT to patients with non-ATM genetic mutations (e.g. BRCA, NF) who elect to have lumpectomy and are otherwise PRIME II/CALGB candidates for RT omission (i.e. low risk disease characteristics: strongly ER+, <1cm, grade 1-2, no LVI, widely negative margins, and committed to endocrine therapy)?
Again, as in the previous hypothetical, this patient is otherwise well-qualified and has chosen to forego surgical prophylaxis. Is she eligible for PBI? If not, she should have whole-breast?… And perhaps contralateral “radiation prophylaxis”? I don’t believe so. In the studies you referenced, we did...
What dose/fractionation would you recommend for primary aneurysmal bone cyst of spine after a subtotal resection?
See the articles below: Mendenhall et al., PMID 16755186 Zhu et al., PMID 26165419