Radiation Oncology
Expert insights on radiation treatment planning, techniques, toxicity management, and multimodal cancer care.
Recent Discussions
What is your management strategy for unresectable endometrial cancer due to gross cervical involvement with parametrial extension?
Our approach is PETCT and MRI for staging. Neoadjuvant chemo RT with external beam and brachy to EQ2 dose of 65-70 Gy folllowed by extrafascial hysterectomy and then adjuvant chemotherapybelow is link to our published datahttps://www.ncbi.nlm.nih.gov/pubmed/25218303
What methods do you use to decrease genital skin reaction when delivering pelvic radiation to patients in the prone position?
If you are seeing skin reactions in the genitalia in females, you are probably affecting their long term sexual function. Patients discontinue their sexual activity due to pain at the introitus when that area is treated. I don't treat patients in the prone position if genitalia sparing necessary as ...
When would you consider treating a testicular relapse with definitive radiation in a child with ALL?
I would strongly advise against treating with testicular radiotherapy alone at relapse given that testicular relapse is often a harbinger for systemic relapse (depending on the length of first clinical remission) which radiotherapy alone strategies will fail to address (PMID: 8275428). Radiotherapy ...
Would you consider SBRT for a retroperitoneal sarcoma with an R2 resection near critical structures precluding re-resection?
This is a great question. The area of risk in R2 resections are the residual disease and the entire retroperitoneum. Thus, if feasible, the post-op retroperitoneal volume should be treated to 66 Gy (due to the R2 resection) as it is at high risk for recurrence. One could consider boosting the residu...
What dose constraints do you use for pituitary in a young woman with completely resected esthesioneuroblastoma?
As low as possible. Not top priority for me but by default it winds up being around 54 or less.
Is extensive abutment of the duodenum without invasion a contraindication to SBRT for pancreatic tumors?
First, let's be clear that we are talking about a palliative (or neoadjuvant) dose of radiation (53Gy BED). A similar dose, 54Gy in 30 fx, failed to improved overall survival in a randomized phase III trial (LAP07). Next, let's consider one of the most fundamental principles in radiotherapy, fractio...
How do you decide when to electively cover ipsilateral level IB or V in a node positive neck?
The primary site of most concern would be the oropharynx and what to do with level IB if the patient is cN+ and the reason is that sparing the submandibular region may lead to decreased toxicity, as it's function provides baseline moisture in the oral cavity (as opposed to the parotid gland, which i...
What margins (CTV and PTV) do you use for boosting breast lumpectomy cavity?
RTOG says: Contour seroma/architectural distortion/relevant clips/lump scar as GTV. Add 1cm expansion for CTV, posteriorly carve til anterior to pec major and don't cross midline; pull into skin 5mm. Add 0.7cm expansion for PTV but exclude heart. Then create PTVeval - pull PTV into skin 5mm, don't ...
Would you recommend reirradiation in a patient who has extensive subcutaneous chest wall nodules and axillary recurrence after previous PMRT?
These are very difficult clinical situations that have nuances that make it hard to give a definitive answer. I would first ask what the status is of any distant disease, and if systemic therapy options have been exhausted. If this is localized disease, if it is symptomatic or about to be, if perfor...
What anatomical sites would you electively cover to intermediate dose for an oropharyngeal primary with clear extension into the nasopharynx?
I have had a case like this and I have to admit, I was not sure what the right thing to do was. How extensive is the NP disease component? Is there perineural spread on MRI? Hpv status? Ultimately, my patient was a light smoker with hpv related disease. I decided to treat more like an oropharynx an...