Rheumatology

Belimumab

Questions discussed in this category

What is typical presentation and time course for belimumab infusion-related depression and/or hallucinations, and how do you approach management?

1 Answer available

Would you continue belimumab in high risk lupus patients with overlapping scleroderma features with ILD who become pregnant and who are already on HCQ and azathioprine?

1 Answer available

Would you consider belimumab for an SLE patient who has generalized hair thinning, leukopenia (WBC <3), low C3, and markedly positive anti-dsDNA who is otherwise asymptomatic?

The patient is already on hydroxychloroquine.

1 Answer available

Would you use belimumab in a breastfeeding patient with SLE who has persistent joint pain, leukopenia and elevated dsDNA despite HCQ and azathioprine?

3 Answers available

How would you approach initiating belimumab in a patient with serologic evidence of prior hepatitis B infection?

Such as patients with negative Hepatitis B surface antigen and negative viral load but with positive hepatitis b core antibody.

1 Answer available

Would you consider adding voclosporin to belimumab and MMF in the setting of active proteinuria, rather than switching agents?

3 Answers available

Would you have any hesitation to use belimumab in a patient with IgA deficiency?

1 Answer available

Is it okay to use belimumab to treat SLE in a patient who has a history of lymphoma and is on a Bruton's tyrosine kinase inhibitor (such as ibrutinib)?

1 Answer available

Do you think there is a role for belimumab in treating lupus nephritis and if so, in which patients would you considering adding it on?

Did the recently published BLISS-LN trial change your practice?

2 Answers available

Papers discussed in this category

N Engl J Med,

Two-Year, Randomized, Controlled Trial of Belimumab in Lupus Nephritis.

Lupus, 2013-02

Safety profile of belimumab: pooled data from placebo-controlled phase 2 and 3 studies in patients with systemic lupus erythematosus.

Rheumatology (Oxford), 2022 Nov 02

British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids.

Rheumatic diseases clinics of North America, 2021 Feb 25

The Categorization of Pain in Systemic Lupus Erythematosus.

Lupus science & medicine, 2023 Jan

Molecular endotypes of type 1 and type 2 SLE.

Arthritis and rheumatism, 2013-07

Vitamin D in systemic lupus erythematosus: modest association with disease activity and the urine protein-to-creatinine ratio.

Arthritis care & research, 2016 Jan

Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.

Lupus, 2014 Feb 06

Vitamin D and cutaneous lupus erythematosus: effect of vitamin D replacement on disease severity.

Annals of the rheumatic diseases, 2023 Oct 12

EULAR recommendations for the management of systemic lupus erythematosus: 2023 update.

Arthritis care & research, 2023 Nov 28

Reference Range of Hydroxychloroquine Blood Levels That Can Reduce Odds of Active Lupus and Prevent Flares.

Lupus, 2022 Nov 30

Dilemma of belimumab therapy (dis)continuation during pregnancy: Results of a retrospective study in eudravigilance.

Lupus, 2024 Apr 09

Considering belimumab during pregnancy: A more viable option over time.

The Lancet. Rheumatology, 2020 Dec 15

Mortality and adverse events of special interest with intravenous belimumab for adults with active, autoantibody-positive systemic lupus erythematosus (BASE): a multicentre, double-blind, randomised, placebo-controlled, phase 4 trial.

Rheumatology

Belimumab

Questions discussed in this category

Papers discussed in this category

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