Could plasmapheresis be reasonably considered in pregnant patients for primary prevention in asymptomatic familial hypercholesterolemia, and if so, is there an LDL cutoff that would prompt consideration to proceed?

Plasmapheresis/LDL apheresis is considered a safe and effective option for maternal LDL-C lowering in pregnancy, especially in women with homozygous FH, where it is considered standard of care. In heterozygous FH, the use of plasmapheresis for primary prevention is reasonable in patients with a true...