Topics:
Radiation Oncology • Genitourinary Cancers
Do you account for prior EBRT when treating with 177Lu-PSMA-617?
If so, how? The trial did not exclude patients who had prior radiation (except hemibody RT) but there is little information on how to estimate dose to certain OARs, such as the cord, in patients with extensive spinal bony metastases, who've had prior palliative EBRT and persistent PSMA PET avid disease with epidural extension.
Answer from: Radiation Oncologist at Academic Institution
No, we do not account for it. In the future, with a better understanding and implementation of Dosimetry, it may be important, particularly as LuPSMA moves into earlier lines of care.Patients receiving this therapy are heavily pretreated often with RT in the VISION study. We use palliative radiation...
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