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Do you avoid the use of GLP-1 R agonist therapy for treatment of obesity in patients with known gastroparesis?
Answer from: at Community Practice
Short answer: yes. Gastroparesis is a well-known side effect of GLP-1 RA therapy. It is dose-dependent, so some patients may tolerate smaller doses but not the highest ones. A recent head-to-head trial of semaglutide vs tirzepatide in obesity (Aronne et al., PMID 40353578) found similar rates of gas...
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