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Do you consider ADT intensification with enzalutamide or abiraterone in patients receiving adjuvant radiation with ADT?

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Mednet Member
Mednet Member
Radiation Oncology · Case Western Reserve University/ University Hospitals Seidman Cancer Center

I agree with Dr. @Dr. First Last.

One thing to note is ~3% of RADICALS, for example, included pT3b and high grade disease, and almost no patients in the ART vs SRT trials had N+ disease. Was largely GS7 and pT3a population and not the very high risk patients that select surgeons choose to operate on....

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Mednet Member
Mednet Member
Medical Oncology · Duke University School of Medicine

The short answer is no. The long answer is that most men even with high risk prostate cancer are presently treated with early salvage RT +/- ADT rather than adjuvant RT +/- ADT given the results of 3 recent phase 3 trials which demonstrated similar results for early salvage radiation vs adjuvant RT,...

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