Do you consider holding PPIs in patients hospitalized with infections like pneumonia or C. diff colitis?

My practice is to try to get patients off PPIs if at all possible, and the hospital can be a good time to have that conversation with them. This is assuming no active indication for them (recent ulcer/upper GI bleed, H.pylori therapy, etc.)

Use of PPIs has been associated with a higher incidence of ...

I think it is a fair opportunity to look into the reason the PPI was started. We often find that they can safely be discontinued if not decreased in frequency/dose.

This study from 2024 doesn't directly answer the question above, but supports the recommendation of stopping PPIs in patients who do not need them.

It shows that continuation of PPIs upon discharge after being started in the ICU is associated with worse outcomes, so any opportunity to stop PPIs if th...