Do you consider omitting adjuvant radiation therapy in an older patient with node positive TNBC who achieve pCR to neoadjuvant chemotherapy?

It depends on what surgery the patient has received.

If lumpectomy plus SLNB, I would not omit unless there is absolute contraindications, intolerance to radiation therapy. PRIME II, CALGB 9343, and this meta-analysis provided evidence that post lumpectomy radiation therapy can be omitted in women >...

I assume you mean lymph node irradiation. This is very clearly dependent on age. Based on retrospective studies which included virtually no patients over 70, I probably would not. There is absolutely no data to show survival in this age group with an average risk of competing causes of death of 4% p...