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Breast Cancer • Medical Oncology • NCI-CCC Tumor Board Question • Triple negative • University of Iowa
Do you consider omitting adjuvant radiation therapy in an older patient with node positive TNBC who achieve pCR to neoadjuvant chemotherapy?
Answer from: Medical Oncologist at Community Practice
It depends on what surgery the patient has received. If lumpectomy plus SLNB, I would not omit unless there is absolute contraindications, intolerance to radiation therapy. PRIME II, CALGB 9343, and this meta-analysis provided evidence that post lumpectomy radiation therapy can be omitted in wo...
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Answer from: Medical Oncologist at Community Practice
I assume you mean lymph node irradiation. This is very clearly dependent on age. Based on retrospective studies which included virtually no patients over 70, I probably would not. There is absolutely no data to show survival in this age group with an average risk of competing causes of death o...