Do you consider using buspirone for the management of anxiety in older patients?

While buspirone has been FDA-approved for the treatment of generalized anxiety disorder (GAD) and for short-term relief of anxiety symptoms in general since the 1970s, it is not generally considered a first-line treatment, despite its low misuse potential as a non-benzodiazepine. There are no large ...

Hydroxyzine... everyone thinks it is anticholinergic since it is an antihistamine like Benadryl, which is anticholinergic. The Ki value for muscarinic receptors is >4000, which is clinically negligible.

End of the day - it's not anticholinergic and is safe to use in the elderly.

On another note, dox...

It is impossible to study GAD with clinical trials and randomized studies, as the condition seems to be the end product of biological, psychological, social, and existential conflicts that surface especially in old age. With that said, buspirone is an excellent choice to weave into a psychotherapeut...

I use Clonidine for GAD, with careful monitoring of blood pressure. I find it to be safe and effective, especially for insomnia, and easy to stop. Excellent results. The main side effect is tiredness, which some people don't tolerate well. For intermittent anxiety and panic attacks, I use propranolo...