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Do you consider younger patients with NF2 to have a relative contraindication to radical pelvic RT due to risk of secondary malignancy?

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Mednet Member
Mednet Member
Radiation Oncology · University of Kentucky

Yes, I would consider NF2 to be a relative contraindication in a young patient. In the situation presented (borderline indications for post-op RT), I would likely lean toward up-front radical hysterectomy. However, if clear indications for post-op RT are present following surgery, I would not hesita...

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Radiation Oncology · Varian Medical Systems/Allegheny health network

The data on NF1 and malignancy is mainly with the transformation of benign tumors to malignancy with RT or new brain gliomas in the RT field. I am not aware of any such risk with pelvic RT unless cutaneous neurofibroma is in the radiation field and would not change management if RT is indicated.

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Do you consider younger patients with NF2 to have a relative contraindication to radical pelvic RT due to risk of secondary malignancy? | Mednet