Do you continue Trikafta throughout pregnancy in a woman with cystic fibrosis who has adequate lung function and is in a stable clinical state, rather than discontinuing therapy out of concern for unknown fetal risk?

I think this is an area where shared decision-making is needed.

My default answer tends to be continue for anybody with CF, as in general, ETI has been found to be safe, except for some increased monitoring for the infants after birth.

If the pregnant person is 100% asymptomatic, has no bronchiectas...