Do you counsel isotretinoin patients to use supplements (fish oil, OTC antihistamines, or Omega 3s) to decrease purging and mucocutaneous dryness?

I felt the original study, showing efficacy of omega-3’s in reducing severe isotretinoin cheilitis, was compelling.

Agreed with the above on omega-3 fatty acids.

I always recommend 2nd gen antihistamines as well (Pandey & Agrawal, PMID 31734672). Harmless addition that seems to not only help some of the symptoms associated with isotretinoin, but also seems to improve efficacy.

Finally, if omega-3s don't help with j...