Do you counsel isotretinoin patients to use supplements (fish oil, OTC antihistamines, or Omega 3s) to decrease purging and mucocutaneous dryness?

Sungkhasunya et al., JAAD 2026

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Do you normally recommend using supplements (ie: fish oils, Omega 3s, etc.) for patients taking isotretinoin?

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2 Answers

Mednet Member

Dermatology · Dermatology Associates of Northern Kentucky

Answered on

Agreed with the above on omega-3 fatty acids.

I always recommend 2nd gen antihistamines as well (Pandey & Agrawal, PMID 31734672). Harmless addition that seems to not only help some of the symptoms associated with isotretinoin, but also seems to improve efficacy.

Finally, if omega-3s don't help with j...

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Mednet Member

Dermatology · Wallis Dermatology Associates

Answered on

I felt the original study, showing efficacy of omega-3’s in reducing severe isotretinoin cheilitis, was compelling.

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