Topics:
Radiation Oncology • Thoracic Malignancies • Medical Oncology • Small cell lung cancer • SWOG
Do you ever withhold PCI for elderly patients with limited stage SCLC?
In elderly patients (>70-75) with a good performance status, does the risk of neurocognitive decline outweigh the benefit of PCI?
Answer from: Radiation Oncologist at Academic Institution
This is a great question, and one that we don't have a definitive answer for at this time. Certainly, PCI is not without its significant side effects, especially on neuro-cognition, and the early clinical trials on PCI in LS-SCLC patients showed a benefit in OS for the entire cohort, but did not str...
Comments
Radiation Oncologist at Lake Cumberland Regional Hospital
The neuro toxicity is minimal. Also to consider da...
The neuro toxicity is minimal. Also to consider da...
Radiation Oncologist at Beaumont Health System
I recommend that patients go on studies such as S-...
I recommend that patients go on studies such as S-...
Answer from: Radiation Oncologist at Academic Institution
This is a great question that touches on potential shifts in the risk-benefit ratio of prophylactic cranial irradiation (PCI) in older patients against a backdrop of larger questions regarding the contemporary overall survival (OS) benefit of PCI in the era of brain MRI surveillance - the latter is ...
Answer from: Medical Oncologist at Community Practice
This is a question that begs for the science and art of oncology. I look at the individual patient, I look at not only calendar age but functional age and comorbidities, and life expectancy. The definition of "elderly" is quite relative.
Advances in intensity-modulated radiotherapy (IMRT) and pre-t...
The risks are real and happen at the lower doses p...
We retrospectively reviewed our limited stage smal...
Great data!
Helpful data @Michael Farris!