Do you find IgA isotypes of anti-beta2-glycoprotein antibodies and anticardiolipin antibodies to be clinically useful in the evaluation for APS?
Do you routinely check IgA anticardiolipin and beta-2 glycoprotein antibody IgA in your practice? And how would a positive result change your management?
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Do anticardiolipin or beta-2 glycoprotein IgA positivity affect your management?
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2 Answers
Mednet MemberInvited Expert
Rheumatology · UTMB Health
Answered on
I would answer yes to this question. We believe an isolated IgA elevation of AcL or anti-B2GPI carries diagnostic relevance in the right clinical context. We routinely look for all Ig isotypes in our diagnostic evaluation of APS. In fact, our group published the first such article.
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Mednet MemberInvited Expert
Rheumatology · UT Southwestern Medical Center
Answered on
There are conflicting views on this topic. A recent study of 1068 persons found that while IgA B2glycoprotein antibodies were associated with APS, isolated IgA antibodies did not portend thrombotic risk. Chayoua et al., PMID 32696448. They are not currently part of the criteria for APS. So my answer...
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