The occurrence of the isolated brain met is assumed to be in a TNBC patient who was diagnosed previously with non metastatic breast cancer and was treated with curative intent (not de novo). The most likely scenario is that the patient harbors occult residual disseminated tumor cells in the marrow w...

Apart from a clinical trial, I would offer observation only and monitor closely. Admittedly, there are no good data to support either approach.

I would not give systemic therapy to a brain only recurrence of TNBC. One might consider this as oligometastatic and justify chemo systemically post brain rx on that premise but I wouldn't. I have a couple of patients with long term remissions (4-5 yrs) with removal of lung lesions with no further s...

Assuming this patient previously received adjuvant chemotherapy (as almost all TNBC do), I would just observe. While the patient is at increased risk of distant recurrence vs. a patient with similar stage of disease at diagnosis and prior treatment, there is no data to suggest that additional 'adjuv...