Do you need to wait for estradiol and FSH levels to normalize before you can switch from tamoxifen to an AI for a pre-menopausal woman with ER+ breast cancer?
What steps should be taken when switching premenopausal women from tamoxifen to AI? In this case, the change is due to newly discovered endometrial thickening. Do you discontinue tamoxifen, start your GnRH agonist, then check if estradiol and FSH levels are in post menopausal range before you can start AI treatment?
1 Answer
Mednet MemberInvited Expert
Medical Oncology · Huntsman Cancer Institute at the University of Utah
Answered on
Since tamoxifen can also affect hormone levels, it is prudent to hold tamoxifen for a month before checking hormone levels. In this case, it is reasonable to stop tamoxifen due to endometrial thickening. One could consider checking hormone levels after a month of stopping tamoxifen and if they are i...
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