Breast Cancer, Non-metastatic   

Questions discussed in this category


In light of updated monarchE trial data, it seems a SLNB would help delineate adjuvant treatment options in this population. However, Choosing Wisely ...

Grade 2 DCIS, post mastectomy with negative margins, sentinel nodes negative

BRCA mutant, ER/PR positive and HER2 positive T2N0M0 breast cancer diagnosed 5 years ago, treated with bilateral mastectomy, BSO, 1 year of adjuvant a...

Patient previously received neoadjuvant ddAC-T with residual disease at surgery, followed by adjuvant capecitabine which was completed 2 months prior ...

For patients with hormone negative breast cancer and HER2 positive only by copy number, do you give TDM1 for residual disease or capecitabine?

Assume normal cardiac function and no obvious co-morbidities. No anthracycline previously due to age alone. The patient’s BRCA status is unknown...

What steps should be taken when switching premenopausal women from tamoxifen to AI? In this case, the change is due to newly discovered endometrial th...

 If blood counts are sustained, do you continue or delay?

TNBC diagnosed in 2nd trimester. Neoadjuvant rx not given due to complicated pregnancy and went straight to surgery due to HR+ biopsy. Surgical pathol...

Should patients with moderate penetrance pathogenic variants be managed similar to BRCA patients and consider risk reducing contralateral mastectomy?&...

Would you consider omitting treatment if small tumor and early stage? Or would you use tamoxifen?

Would you consider neoadjuvant or adjuvant treatment and if so, which therapies? Patient initially had pT2N0 disease and recurrent disease is also ER+...

Patient had estradiol level checked by her gynecologist due to recent irregular bleeding. Estradiol level was markedly elevated on initial testing (90...

Patient had an initial tumor response to TCHP, but still had significant residual disease present, including positive lymph nodes and residual breast ...

Given that olaparib was given within 12 weeks of completion of standard adjuvant therapy on the trial, will you still offer it to patients outside tha...

The patient was diagnosed with Ewing’s Sarcoma at the age of 10 and completed 6 cycles of vincristine, ifosfamide, etoposide, adriamycin 75mg/m2...

In patients who have completed all adjuvant therapy. Similar test to what is available for stage 2 and 3 colon cancer patients by Natera.

Assuming FDA approval of the drug for adjuvant use, do you perceive a difference between somatic vs germline BRCA mutations? 

38 y/o female had a biopsy of a palpable mass that showed G3 IDC with 80% ER+, 90% PR+, and HER2 positive (IHC 2+; 1.6 HER2/CEP17 ratio and 6.3 HER2 c...

The GeparSixto, CALGB 40603, and more recently Prospero support doing it; however, it is not currently endorsed by NCCN and the latter Prospero s...

The use of neoadjuvant CDK 4/6 inhibitors is not standard of care, but there are clinical trials looking at this question and patients who are chemoth...


Papers discussed in this category


Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-01-01

N. Engl. J. Med.,

Lancet Oncol., 2014-06-01

The Lancet. Oncology, 2018-04

JAMA Oncol,

Nat. Med.,

J. Clin. Oncol., 2018 Dec 06

Annals of oncology : official journal of the European Society for Medical Oncology, 2005-08

J. Clin. Oncol., 2020 Sep 20

J Clin Oncol, 2020 Oct 27

Annals of Oncology, 2021 Sep 29

J Clin Oncol, 2021 Feb 04

The New England journal of medicine, 2018-07-12

Thromb Haemost,

J Clin Oncol, 2020 Oct 29

N Engl J Med, 2021 Jun 03

N. Engl. J. Med.,

J Clin Oncol, 2019 Apr 11

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-08-10

JAMA Oncol,

JAMA, 2011-02-09

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-04-10

Ann Oncol,

J Clin Oncol, 2021 Jun 06

JAMA oncology, 2017-11-01

Clin Cancer Res,

J Natl Cancer Inst, 2011 Jul 09

Br J Clin Pharmacol, 2020 Jun 02

Am J Surg Pathol, 2021 Jun 10

Breast Cancer Res, 2020 Nov 04

The New England journal of medicine, 2019-02-14

PLoS One, 2013 Oct 09

Clin Breast Cancer, 2020 Oct 06

Mol Cell Endocrinol, 2021 Jan 26

Journal of the National Comprehensive Cancer Network : JNCCN, 2017-10

Clinical cancer research : an official journal of the American Association for Cancer Research, 2018-12-01

The Lancet. Oncology, 2014-02

N. Engl. J. Med., 2017 Jun 04

J. Clin. Oncol., 2018 May 30

Ann. Oncol.,

Biomark Med, 2018 Dec 19

Biomark Med, 2019 Jun 25

The New England journal of medicine, 2004-09-02

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013-07-01

N Engl J Med,

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-08-01

Annals of oncology : official journal of the European Society for Medical Oncology, 2012-06

Br J Cancer, 2019 Jan 17