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Do you offer adjuvant osimertinib to EGFR exon 19 deleted patients with T2N0 NSCLC treated with definitive SBRT?

I.e. based on the findings of ADAURA in surgically managed patients.
2 Answers
Mednet Member
Mednet Member
Radiation Oncology · Tennessee Oncology
Answered on

Given the fairly striking benefit of ADAURA in resected patients, there likely would be a locoregional and distant control and likely survival benefit to this approach but we don't have data to support this. PACIFIC-4 is currently enrolling. Study of durvalumab vs placebo in patients with early stag...

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Mednet Member
Mednet MemberInvited Expert
Medical Oncology · Wexner Medical Center at The Ohio State University
Answered on

Recent press release data (presumably to be presented at an upcoming meeting) states that there is a survival benefit for adjuvant osimertinib in the ADAURA study. That said, I do not offer adjuvant osimertinib to EGFR exon 19 deleted patients with T2N0 disease following SBRT. This certainly warrant...

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