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Do you offer adjuvant therapy for localized medullary carcinoma of the ascending colon that is MSI-H?

Do you use the same high risk factors as adenocarcinoma when deciding on adjuvant treatment for early stage disease?
1 Answer
Mednet MemberInvited Expert
Medical Oncology · Indiana University Melvin and Bren Simon Cancer Center
Answered on

Medullary carcinoma of the colon is a rare type of colon cancer with unique clinical and molecular features. Despite its high-grade histology, its prognosis is generally better than adenocarcinoma. They tend to be locally advanced and rarely metastasize. They are usually MSI-H with a high number of tumor-infiltrating lymphocytes on pathology.

Because this is a rare sub-type of colon cancer, there is no randomized data studying the role of chemotherapy in these patients. If the patient is stage ...

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