Do you offer consolidation chemotherapy prior to durvalumab in locally advanced, unresectable NSCLC?
I do not offer consolidation chemotherapy to patients prior to durvalumab in patients with locally advanced, unresectable NSCLC. The PACIFIC trial was a randomized phase III trial that established the role of consolidation durvalumab after definitive chemoradiation for patients with stage III NSCLC....
Despite several approaches to improve outcomes for patients with unresectable stage III NSCLC over the past decades, none have been shown to increase survival before the addition of consolidation durvalumab in the PACIFIC trial. The addition of consolidation chemotherapy was shown to lead to increas...
Ever since the publication of the PACIFIC trial which allowed “induction” chemotherapy prior to chemoradiation but no “consolidation” chemotherapy, I have not been using consolidation chemotherapy. Given that the last 25+ years have barely (if at all) moved the needle (with induction, consolidation,...