Do you offer hypofractionated courses of radiation with temozolomide for "elderly" patients with GBM?

Does the MGMT status change your decision-making? Should we be routinely testing MGMT for elderly patients?

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Do you offer hypofractionated courses of radiation with concurrent and adjuvant temozolomide for elderly patients with GBM?

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3 Answers

Mednet MemberInvited Expert

Radiation Oncology · Kaiser Permanente

Answered on

The ASTRO GBM guideline states the following with regard to elderly patients:

“Given the absence of proven superiority for conventionally fractionated radiation therapy, the panel recommends hypofractionated radiation therapy for elderly patients with fair-good performance status (high quality eviden...

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Radiation Oncology · University of North Carolina

Answered on

This question has been asked in a randomized clinical trial, "A phase III randomized controlled trial of short-course radiotherapy with or without concomitant and adjuvant temozolomide in elderly patients with glioblastoma" and will be presented at the ASCO Annual Meeting Plenary Session by James Pe...

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Radiation Oncology · Columbia University Irving Medical Center

Answered on

Yes, we do offer hypofractionated RT for elderly GBM patients off trial.

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