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Do you offer liver SBRT for metastatic colorectal cancer after local recurrence following previous treatments such as radiofrequency ablation (RFA), radioembolization, and chemoembolization?

If so, what dose fractionation do you prefer?
1 Answer
Mednet MemberInvited Expert
Radiation Oncology · Mayo Clinic Rochester
Answered on

I do offer liver SBRT for local recurrence after other liver directed therapies. With regard to RFA, there have been a number of single institution retrospective studies suggesting that RFA has a higher recurrence rate than SBRT for lesions larger than 2-3 cm (Jackson et al., IJROBP 2018; Franzese et al., J Cancer Res Clin Oncol, 2018). I treat the local recurrence, and if I can meet liver constraints, the entire ablation cavity to 45-60 Gy/3 fractions or 50-60 Gy/5 fractions. Colorectal metasta...

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