I prefer using CNIs over MMF as a steroid-sparing agent. It is important to note that the mechanism of action of CNIs in glomerular disease is likely not just from its immunomodulatory effects as CNIs can also cause stabilization of the podocyte cytoskeleton Peleg et al., PMID 32152065

For frequently relapsing or Steroid-dependent MCD, the choices are: Cyclophosphamide Calcineurin inhibitors Mycophenolate analogs Rituximab Currently, I almost exclusively use rituximab, given its efficacy and safety (and convenience). In the event of rituximab not being available, CNI's a...