Do you recommend adjuvant chemotherapy to a low risk T3N0 stage II colon cancer if there was bowel perforation upstream from the tumor, with mucosa underlying tumor itself being intact?
Does a bowel perforation near by a tumor impose as much risk of recurrence as the tumor itself being perforated? Should that be a risk factor taken into account when deciding adjuvant therapy?
1 Answer
Mednet MemberInvited Expert
Medical Oncology · University of Wisconsin
Answered on
The upstream perforation is likely from another cause like inflammatory bowel disease, I am assuming. In this situation, I would offer chemo regardless of the upstream perforation. I would consider if they are eligible for a clinical trial that is incorporating ctDNA to help decide. But my understan...
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