Do you recommend adjuvant RT to patients with non-ATM genetic mutations (e.g. BRCA, NF) who elect to have lumpectomy and are otherwise PRIME II/CALGB candidates for RT omission (i.e. low risk disease characteristics: strongly ER+, <1cm, grade 1-2, no LVI, widely negative margins, and committed to endocrine therapy)?

1 Answers

Mednet Member

Radiation Oncology · Cooper Medical School of Rowan University/Cooper University Hospital

Again, as in the previous hypothetical, this patient is otherwise well-qualified and has chosen to forego surgical prophylaxis. Is she eligible for PBI? If not, she should have whole-breast?… And perhaps contralateral “radiation prophylaxis”?

I don’t believe so. In the studies you referenced, we did...