Do you recommend CDK4/6 inhibitor, radiotherapy, or both following surgery for a pathologic fracture from HR+ breast cancer?
Has anyone omitted post path fracture radiation of pelvis/long bone in favor of starting endocrine treatment first? Or would one omit RT and start a CDK 4/6 inhibitor? Or would it be reasonable to give concurrent CDK 4/6 inhibitor with xrt?
Answer from: Radiation Oncologist at Community Practice
The goal of therapy is to help control pain and enhance healing. Post-op RT is routine with the most common dose used by us being 20 Gy in 5. It’s reasonable to do with concurrent CDK4/6 inhibitor.https://www.ncbi.nlm.nih.gov/pubmed/31360799
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