Do you recommend holding a TKI when treating brain metastases with SRS/WBRT?

Topics: Lung Cancer • Radiation Oncology • Palliation • Neuro-Oncology • Thoracic Malignancies • Stereotactic Radiosurgery • Brain Metastases

Is there evidence that supports/refutes the safety of concurrent use?

Answer from: Radiation Oncologist at Academic Institution

There are a few publications which help address this very pertinent question. The phase 3 trial of whole brain radiation therapy (WBRT) and stereotactic radiosurgery (SRS) alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: RTOG 0320 (...

Comments

Radiation Oncologist at Naval Medical Center San Diego
When would you recommend a pt stop Erlotinib prior...

Radiation Oncologist at Vanderbilt-Ingram Cancer Center
We usually do not hold erlotinib for a patient rec...

Radiation Oncologist at Radiation Oncology of Atlanta
For a patient who has had an isolated calvarial me...

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