Do you recommend holding a TKI when treating brain metastases with SRS/WBRT?
Is there evidence that supports/refutes the safety of concurrent use?
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Do you recommend holding a TKI when treating brain metastases with SRS?
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1 Answer
Mednet MemberInvited Expert
Radiation Oncology · University of Toronto Faculty of Medicine
Answered on
There are a few publications which help address this very pertinent question. The phase 3 trial of whole brain radiation therapy (WBRT) and stereotactic radiosurgery (SRS) alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: RTOG 0320 (...
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