Do you recommend neoadjuvant radiation or chemoradiation for patients with T1-2 N0 adenocarcinoma of the anal canal prior to APR?

For the most part, anal adenocarcinoma is treated like rectal adenocarcinoma. Therefore, as the question is written, i.e. the patient will be getting an APR, I don't think there is enough data of a benefit for treating a T1-2 N0 adenocarcinoma with chemoradiation to justify the toxicity.

However, if the colorectal surgeon involved believes downstaging may allows a local excision, or if non-operative management is being contemplated, these approaches could justify chemoradiation. I would not fav...

Yes followed by transanal excision if feasible