Do you recommend neoadjuvant radiation or chemoradiation for patients with T1-2 N0 adenocarcinoma of the anal canal prior to APR?

For the most part, anal adenocarcinoma is treated like rectal adenocarcinoma. Therefore, as the question is written, i.e. the patient will be getting an APR, I don't think there is enough data of a benefit for treating a T1-2 N0 adenocarcinoma with chemoradiation to justify the toxicity.

However, i...

Yes followed by transanal excision if feasible