Do you recommend ovarian suppression in all premenopausal women under age 35 with ER positive breast cancer based on the SOFT/TEXT data, regardless of other risk features?

I do not recommend ovarian suppression on all women under 35. Like any intervention, we need to know the absolute risks of recurrence with and without the intervention.

For these reasons, given the side effect profile of ovarian suppression in younger women, I usually reserve it for women with large...

According to our guidelines, age per se should not be considered a reason for administering more aggressive treatments (including chemotherapy and/or a more aggressive endocrine treatment). However, younger age (< 35 years) is known to be a poor prognostic factor and being associated with a higher i...