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Endocrinology • Diabetes
Do you recommend switching from a GLP-1 agonist to insulin in female patients with type 2 diabetes who are planning to become pregnant?
Answer from: at Community Practice
Animal studies have indicated a potential for reproductive toxicity at maternally toxic doses of Semaglutide, Dulaglutide and Exenatide.Due to the paucity of data with Semaglutide and Human pregnancy, the manufacturer advises stopping the drug 2 months before conception.However, in a multicentric st...
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Answer from: at Academic Institution
The GLP-1 receptor agonist drugs are contraindicated in pregnancy (pregnancy category C). In women planning to get pregnant, who are on one of these drugs, I would consider switching to metformin if they are not already on it. Of course, insulin can be prescribed if necessary.