Do you recommend treatment for CLL patients with biopsy proven infiltrative lesions in the liver without hepatic dysfunction or hepatomegaly?

Would you initiate treatment in a patient with biopsy proven infiltrative CLL liver lesions, with no hepatic dysfunction or hepatomegaly?

• Yes, I would initiate treatment immediately
• No, I would proceed with close observation and treat only if/when more typical indications for treatment emerge
• Only if other sites or manifestations of disease are present
• Other