Do you routinely continue using TPA/Dornase for treatment of empyema, if there is accumulation of new sero-sanguinous output from the chest tube after the initial treatment?

In my practice, if there is an accumulation of serosanguinous output after initial treatment, further treatment with tPa/ dornase depends on several factors.

1. Hct of drainage - if > 50%, will not give further dose.
2. If a patient is coagulopathic or receiving anticoagulation for a medical condition af...