Do you routinely offer PMRT for T3N0 breast cancer?

• Yes, especially in young women. The Danish PMRT trial included T3N0 patients, and in the pre-menopausal group, there was a meaningful increase in overall survival (10-year actuarial survival 82% vs 70%, with vs without PMRT; Overgaard et al., PMID 9395428). Now, one can argue that this is an old ...

I do not routinely offer PMRT for T3N0. From the data published from NSABP and others, it seems to be that the biology of these tumors is different and the risk of local failure is rather low (around 7%). However, if I see risk factors like LVI, young age (may be <50), grade III, close margins, or p...

There is hardly any prospective data focusing specifically on T3N0 postmastectomy and there has never been any data demonstrating a benefit of PMRT in this setting. Our group published a SEER study in 1,865 patients demonstrating no improvement in 10-yr cause specific survival with PMRT overall, and...