Do you routinely prescribe linezolid to patients who are concomitantly on methadone?

There are a few ways to interpret this question:

1. Potential for serotonin syndrome with possible interaction between methadone and linezolid.
2. Potential for further QTc prolongation with the addition of linezolid to methadone.
3. Whether empiric oral antibiotics (when IV antibiotics could be used) are ...

Yes. This is not a clinically significant drug-drug interaction.